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Grief pill study stalls: naltrexone trial ends early

NCT ID NCT06140420

Terminated Symptom relief Sponsor: Texas Tech University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether the drug naltrexone could help people with prolonged grief disorder, a condition where grief lasts a long time and causes severe distress. Participants took naltrexone or a placebo for 8 weeks and had monthly check-ins. However, the study was terminated early and only included 7 people, so it does not provide clear answers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Naltrexone (oral tablet)
What this could lead to
If it worked, this could point toward a medication to ease the intense pain of prolonged grief disorder.
What could go wrong
The study was terminated early and only enrolled 7 people, so we cannot draw reliable conclusions. Naltrexone may cause side effects like nausea or headache.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NALTREXONE HCL 50 MG ORAL TABLET PLACEBO

Contacts and locations

Locations

  • Texas Tech Health Science Center

    Lubbock, Texas, 79409, United States

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