Could MRI spot prostate cancer earlier in High-Risk men?
NCT ID NCT01990521
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 2 times
Summary
Men with BRCA1 or BRCA2 gene mutations have a higher risk of early and aggressive prostate cancer. This study tests whether using a special MRI (multispectral 3T MRI) can find prostate cancer earlier than standard PSA and digital rectal exams. Sixty men aged 50 and older with BRCA mutations will get an MRI followed by a biopsy to see how well the MRI detects cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Multispectral 3T MRI and transrectal ultrasound-guided biopsy
What this could lead to
If successful, MRI could become a standard screening tool to catch prostate cancer earlier in men with BRCA mutations, potentially improving outcomes.
What could go wrong
This is a small, early study (60 participants) and it's unclear if MRI will be more effective than current PSA and DRE screening. The results may not apply to all men with BRCA mutations.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Sunnybrook Odette Cancer Centre
Toronto, Ontario, M4N 3M5, Canada