New hope for advanced breast cancer: umbrella trial tests multiple drug cocktails

NCT ID NCT04802759

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 06, 2026 · Updated 5 times

Summary

This study is testing several different drug combinations in people with advanced ER-positive breast cancer that has stopped responding to prior treatments. The trial is designed like an 'umbrella,' allowing new drug combos to be added as they become available. About 316 participants will be enrolled across three groups based on their cancer type and previous treatments. The goal is to see which combinations shrink tumors and are safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Giredestrant, abemaciclib, ipatasertib, and other drug combinations
What this could lead to: If successful, this could identify effective new drug combinations for advanced breast cancer that has stopped responding to standard treatments.
What could go wrong: This is an early-phase trial (Phase 1/2) with a small number of participants. Many drug combinations may not work or could cause serious side effects. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

estrogen-receptor positive breast cancer hormone receptor-positive breast cancer Neoplasm Metastasis triple-positive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INOPERABLE, LOCALLY ADVANCED OR METASTATIC, ER-POSITIVE BREAST CANCER

Contacts and locations

Locations

Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Assuta Medical Centers
RECRUITING

Tel Aviv, 6971028, Israel
Centro Integral Oncológico Clara Campal Ensayos Clínicos START
RECRUITING

Madrid, 28050, Spain
City of Hope
RECRUITING

Duarte, California, 91010, United States
City of Hope - Orange County Lennar Foundation Cancer Center
RECRUITING

Irvine, California, 92618-2377, United States
Flinders Medical Centre
RECRUITING

Bedford Park, South Australia, 5042, Australia
Hadassah Ein Karem Hospital
RECRUITING

Jerusalem, 91120, Israel
Hospital Clinico Universitario de Valencia
RECRUITING

Valencia, 46010, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Vall d Hebron
RECRUITING

Barcelona, 08035, Spain
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28204, United States
Linear Clinical Research Limited
RECRUITING

Nedlands, Western Australia, 6009, Australia
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
RECRUITING

Santa Monica, California, 90404, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
National Cancer Center
RECRUITING

Goyang-si, 10408, South Korea
Peninsula Health-Frankston Hospital
RECRUITING

Frankston, Victoria, 3199, Australia
Peter Maccallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia
Rabin MC
RECRUITING

Petah Tikva, 4941492, Israel
Rambam Medical Center
RECRUITING

Haifa, 3109601, Israel
Regional Cancer Care Associates LLC (RCCA) - Freehold Location
WITHDRAWN

Freehold, New Jersey, 07728, United States
Regional Cancer Care Associates LLC ? Howell Division
WITHDRAWN

Howell Township, New Jersey, 07731, United States
Samsung Medical Center
RECRUITING

Seoul, (0)6351, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital
RECRUITING

Seoul, 3722, South Korea
Shaare Zedek Medical Center
RECRUITING

Jerusalem, Jerusalem, 9103102, Israel
Stanford Cancer Institute (SCI)
RECRUITING

Stanford, California, 94305, United States
Tel Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
The Chaim Sheba Medical Center
RECRUITING

Ramat Gan, 52621, Israel
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
University of California, San Francisco (UCSF)
RECRUITING

San Francisco, California, 94143, United States
University of Pittsburgh Cancer Institute
WITHDRAWN

Pittsburgh, Pennsylvania, 15219, United States
West Cancer Center
RECRUITING

Germantown, Tennessee, 38138, United States

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