Blue dye could make thyroid cancer surgery safer and more precise
NCT ID NCT07354698
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether injecting a blue dye called mitoxantrone hydrochloride into the thyroid during robotic surgery helps surgeons see and remove cancer-affected lymph nodes while avoiding the parathyroid glands. 114 people with papillary thyroid cancer will be randomly assigned to get the dye or not. The goal is to see if the dye reduces accidental removal of parathyroid glands and improves lymph node removal.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- mitoxantrone hydrochloride injection (a blue dye used as a lymphatic tracer)
- What this could lead to
- If it works, this dye could help surgeons remove more cancer-affected lymph nodes while sparing healthy parathyroid glands, reducing complications like low calcium levels.
- What could go wrong
- This is a small, early-phase trial (114 people) testing a dye, not a treatment. The dye may not improve outcomes, and there are risks from the surgery itself and possible allergic reactions to the dye.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Daping Hospital
Chongqicun, 400042, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Real-Time tissue test may help surgeons avoid unnecessary neck dissections in thyroid cancer
- Hidden thyroid cancers: how common are they in patients with thyroiditis?
- New thyroid test aims to cut unnecessary surgeries
- Radioactive iodine: unnecessary for some thyroid cancer patients?
- Pee power: urine test could replace blood draws for thyroid cancer Follow-Up
- Urine test may spot hidden thyroid cancer, avoid unnecessary surgery