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Can a squirt of heart medicine boost bypass success?

NCT ID NCT06301880

Knowledge-focused Sponsor: Damascus University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether applying the drugs milrinone or nitroglycerin directly onto a blood vessel used in heart bypass surgery could improve blood flow. Forty-six patients having elective bypass surgery were randomly assigned to receive one of the two drugs or a saltwater solution. The goal was to see if either drug increased blood flow from the internal mammary artery during the operation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
milrinone or nitroglycerin
What this could lead to
If it works, this could point toward a simple way to improve blood flow during heart bypass surgery, potentially leading to better surgical outcomes.
What could go wrong
This is a small, completed trial with only 46 participants, so results may not apply to all patients. The intervention is applied during surgery and only affects blood flow at that moment, not long-term health.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

46 people

The number who actually took part.

Started

Jan 2022

Finished

Jan 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients undergoing elective primary coronary artery bypass grafting Exclusion Criteria: * patients who developed ischemic events during surgery

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Conditions

The condition(s) this trial relates to.

Aneurysm Spasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Internal mammary artery syndrome Vasodilation

Contacts and locations

Locations

  • Damascus University Cardiac Surgery Hospital

    Damascus, Syria

More trials for these conditions

Other studies related to the condition(s) this trial covers.