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Can a squirt of heart medicine boost bypass success?

NCT ID NCT06301880

Completed Knowledge-focused Sponsor: Damascus University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether applying the drugs milrinone or nitroglycerin directly onto a blood vessel used in heart bypass surgery could improve blood flow. Forty-six patients having elective bypass surgery were randomly assigned to receive one of the two drugs or a saltwater solution. The goal was to see if either drug increased blood flow from the internal mammary artery during the operation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
milrinone or nitroglycerin
What this could lead to
If it works, this could point toward a simple way to improve blood flow during heart bypass surgery, potentially leading to better surgical outcomes.
What could go wrong
This is a small, completed trial with only 46 participants, so results may not apply to all patients. The intervention is applied during surgery and only affects blood flow at that moment, not long-term health.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Aneurysm Spasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTERNAL MAMMARY ARTERY SYNDROME VASODILATION

Contacts and locations

Locations

  • Damascus University Cardiac Surgery Hospital

    Damascus, Syria

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