Heart drug may shield tiny babies from deadly Post-Surgery syndrome

NCT ID NCT06679855

Recruiting now Prevention Sponsor: NICHD Neonatal Research Network Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study tests if the drug milrinone can prevent a serious heart complication called post-ligation cardiac syndrome (PLCS) in very preterm infants after surgery to close a heart vessel. About 316 babies born before 28 weeks will receive either milrinone or standard care. The goal is to see if milrinone reduces death or PLCS within a week and improves survival and brain development at age two.

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Conditions

The condition(s) this trial relates to.

patent ductus arteriosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST-LIGATION CARDIAC SYNDROME

Contacts and locations

Locations

Boston Children's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Case Western Reserve University
RECRUITING

Cleveland, Ohio, 44106, United States
Children's Hospital of Orange County
NOT_YET_RECRUITING

Orange, California, 92868, United States
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States
Duke University
RECRUITING

Durham, North Carolina, 27705, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Le Bonheur Children's Hospital
RECRUITING

Memphis, Tennessee, 38103, United States
Northwestern Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Sharp Mary Birch Hospital for Women & Newborns
NOT_YET_RECRUITING

San Diego, California, 92123, United States
Stanford University
RECRUITING

Palo Alto, California, 94304, United States
University of Alabama - Birmingham
NOT_YET_RECRUITING

Birmingham, Alabama, 35249, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Mississippi Medical Center
NOT_YET_RECRUITING

Jackson, Mississippi, 39216, United States
University of New Mexico
RECRUITING

Albuquerque, New Mexico, 87131, United States
University of Oklahoma Health Sciences
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Texas Southwestern
RECRUITING

Dallas, Texas, 75390, United States
University of Texas at Houston
RECRUITING

Houston, Texas, 77030, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84108, United States

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