Microdosing magic mushrooms: a new hope for depression?
NCT ID NCT05259943
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether very small, non-hallucinogenic doses of psilocybin (the active ingredient in magic mushrooms) can safely improve mood in people with major depression. Thirty-nine adults received either psilocybin or a placebo, then switched. Researchers measured changes in depression, anxiety, and physical symptoms using a standard questionnaire.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
psilocybin (a psychedelic compound found in magic mushrooms)
What this could lead to
If it works, this could point toward a new way to ease depression symptoms without the intense effects of full-dose psychedelics.
What could go wrong
This is a small, early-phase trial with only 39 people, so results may not apply to everyone. The tiny dose might not be strong enough to help, and long-term effects are unknown.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Psych Research
Toronto, Ontario, Canada