Microdosing magic? small psilocybin doses tested for depression

NCT ID NCT05259943

First seen Jan 05, 2026 · Last updated May 16, 2026 · Updated 18 times

Summary

This study tested whether very small, non-hallucinogenic doses of psilocybin (2 mg) could safely improve mood in 39 adults with major depressive disorder. Participants took the microdose and researchers measured changes in depression, anxiety, and physical symptoms using a standard questionnaire. The goal was to see if this approach could ease symptoms without causing a full psychedelic experience.

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Contacts and locations

Locations

  • Psych Research

    Toronto, Ontario, Canada

Conditions

Explore the condition pages connected to this study.