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Could a simple shot replace spinal morphine for C-Section pain?

NCT ID NCT07777029

Symptom relief Sponsor: Clinica Alemana de Santiago Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This trial tests whether a subcutaneous (under-the-skin) injection of methadone can provide pain relief after a cesarean section that is just as good as the standard spinal morphine. The study will enroll 128 women having planned C-sections and measure their quality of recovery over the first 24 hours, along with pain levels, opioid use, and side effects. If methadone works as well, it could offer a simpler and potentially safer option for post-surgical pain management.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Subcutaneous methadone
What this could lead to
If effective, this could offer a simpler, safer alternative to spinal morphine for managing pain after cesarean delivery, potentially improving recovery and reducing side effects.
What could go wrong
This is a non-inferiority trial, so it may only show methadone is no worse, not better. It's also a single study with 128 participants, and results may not apply to all settings or populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 128 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women aged 18-45 years * Singleton pregnancy at term (≥37 weeks of gestation) * Scheduled for elective cesarean delivery * Planned neuraxial spinal anesthesia * Ability to understand and complete the QoR-10 questionnaire * Provision of written informed consent Exclusion Criteria: * Emergency cesarean delivery * Contraindication to neuraxial anesthesia * Known hypersensitivity or allergy to methadone or morphine * Chronic opioid use or opioid dependence

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cesarean section pain

How to take part

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  1. The official record

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