Gene therapy cocktail takes aim at Hard-to-Treat melanoma
NCT ID NCT01397708
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tested a new approach for people with advanced melanoma that cannot be removed by surgery. The treatment combines a gene therapy injected directly into tumors with an oral drug that activates the therapy. The goal was to see if the combination is safe and tolerable. 26 participants were enrolled, and the study is now complete.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a gene therapy (Ad-RTS-hIL-12) injected into tumors plus an oral activator drug (veledimex)
- What this could lead to
- If it works, this could point toward a new way to treat advanced melanoma by boosting the immune system directly inside tumors.
- What could go wrong
- This is an early-phase trial with only 26 people, so results may not apply broadly. The treatment involves gene therapy and can cause side effects like inflammation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Atlantic Melanoma Center
Morristown, New Jersey, 07960, United States
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Fletcher Allen Health
Burlington, Vermont, 05401, United States
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Indiana University Health Goshen Center for Cancer Care
Goshen, Indiana, 46526, United States
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James Graham Brown Cancer Center
Louisville, Kentucky, 40202, United States
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Mary Crowley Cancer Research Center
Dallas, Texas, 75201, United States
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Oncology Specialists
Park Ridge, Illinois, 60068, United States
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St. Lukes
Easton, Pennsylvania, 15232, United States
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The Angeles Clinic
Los Angeles, California, 90404, United States
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Washington University
St Louis, Missouri, 63110, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can new drug cocktails reawaken the immune system against melanoma?
- Could a Six-Month exercise and diet plan shield muscle during melanoma treatment?
- Quitting before the knife: which Stop-Smoking aid works best for cancer patients?
- Can a One-Two punch of immune boosters revive cancer treatment?
- Can a modified herpes virus turn the tide against advanced cancer?
- Can your genes predict your melanoma risk?