Three-Drug attack on deadly skin cancer enters final testing phase

NCT ID NCT04657991

Summary

This study is testing if adding two oral drugs (encorafenib and binimetinib) to a standard immunotherapy (pembrolizumab) works better for people with advanced melanoma that has a specific BRAF gene mutation and hasn't been treated before. About 257 participants will be randomly assigned to receive either the three-drug combination or the standard drug plus a placebo. The main goal is to see if the combination is safe and more effective at shrinking tumors and controlling the cancer.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for MELANOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Locations

  • A.O.U.S. Policlinico "Le Scotte"

    Siena, SI, 53100, Italy

  • AO di Perugia - Ospedale S. Maria della Misericordia, S.C Oncologia Medica

    Perugia, 06132, Italy

  • Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda EAD

    Sofia, 1407, Bulgaria

  • AdventHealth Hematology and Oncology

    Orlando, Florida, 32804, United States

  • AdventHealth Orlando

    Orlando, Florida, 32804, United States

  • AdventHealth Orlando Infusion Center

    Orlando, Florida, 32804, United States

  • AdventHealth Orlando, Investigational Drug Services

    Orlando, Florida, 32804, United States

  • Ars Medika Center, LLC

    Kaliningrad, Russia

  • Azienda Sanitaria Universitaria Friuli Centrale

    Udine, Friuli Venezia Giulia, 33100, Italy

  • BIH of Omsk Region "Clinical Oncological Dispensary"

    Omsk, 644046, Russia

  • BRCR Global Mexico - CDMX

    Mexico City, 01120, Mexico

  • Barts Health NHS Trust.

    London, E1 1FR, United Kingdom

  • CHU Grenoble Alpes

    La Tronche, 38700, France

  • CHU d'Amiens - Hôpital Nord

    Amiens, 80054, France

  • CHU de Poitiers

    Poitiers, 86000, France

  • CHUAC-Hospital Teresa Herrera

    A Coruña, 15006, Spain

  • CIUSSS du Saguenay-Lac-Saint-Jean

    Chicoutimi, Quebec, G7H 5H6, Canada

  • CNI KRC "Regional Cardiology Centre"

    Kharkiv, 61166, Ukraine

  • Charité Universitaetsmedizin Berlin - Campus Mitte

    Berlin, 10117, Germany

  • Clinica Viedma S. A

    Viedma, Río Negro Province, 8500, Argentina

  • Cliniques universitaires Saint-Luc

    Brussels, 1200, Belgium

  • Communal Noncommercial Enterprise of Lviv Regional Council "Lviv Oncological Regional Therapeutical

    Lviv, 79031, Ukraine

  • Complejo Hospitalario de Jaen

    Jaén, 23007, Spain

  • Complex Oncology Center - Plovdiv EOOD

    Plovdiv, 4004, Bulgaria

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032, Hungary

  • Derzhavna ustanova Instytut zahalnoi ta nevidkladnoi khirurhii im.V.T.Zaitseva Natsionalnoi akademii

    M. Kharkiv, 61103, Ukraine

  • Drs Alberts Bouwer Jordaan

    Pretoria, South Africa

  • Drs Alberts, Bouwer and Jordaan Inc.

    Pretoria, Gauteng, 0081, South Africa

  • El Cielo Medical Center RSB, S.C

    Puebla City, 72160, Mexico

  • Eurocityclinic LLC

    Saint Petersburg, 197022, Russia

  • Fachklinik Hornheide

    Münster, 48157, Germany

  • Fakultni nemocnice Bulovka

    Praha 8-Liben, 180 81, Czechia

  • Fakultni nemocnice Ostrava

    Ostrava-Poruba, 708 52, Czechia

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, MI, 20133, Italy

  • Fundacion Instituto Valenciano de Oncologia

    Valencia, 46009, Spain

  • Fundação Pio XII - Hospital de Câncer de Barretos

    Barretos, São Paulo, 14784-400, Brazil

  • General Hospital of Athens "Laiko"

    Athens, Attikí, 11527, Greece

  • HELIOS Klinikum Erfurt

    Erfurt, 99089, Germany

  • Hadassah Medical Organization, Hadassah Medical Center, Ein-Karem

    Jerusalem, 9112001, Israel

  • Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)

    Helsinki, 00029, Finland

  • Hospital Clinic Barcelona

    Barcelona, 08036, Spain

  • Hospital Clinico Universitario Virgen de la Arrixaca

    El Palmar, Murcia, 30120, Spain

  • Hospital Regional Universitario de Malaga - Hospital Civil

    Málaga, 29011, Spain

  • Hospital Sírio-Libanês - Unidade Bela Vista

    São Paulo, 01308-050, Brazil

  • Hospital Universitari Vall D'Hebron, Servicio de Oncología Médica

    Barcelona, 08035, Spain

  • Hospital Universitario Arnau de Vilanova

    Lleida, 25198, Spain

  • Hospital Universitario Marqués de Valdecilla

    Santander, Cantabria, 39008, Spain

  • Hospital Universitario Miguel Servet

    Zaragoza, 50009, Spain

  • Hospital Universitario Puerta de Hierro Majadahonda

    Majadahonda, Madrid, 28222, Spain

  • Hospital Universitario Ramón y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Reina Sofía

    Córdoba, 14004, Spain

  • Hospital Universitario Virgen Macarena

    Seville, 41009, Spain

  • Hospital Universitario Virgen del Rocio

    Seville, 41013, Spain

  • Hospital de Clinicas de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

  • Hospital de Clínicas de Passo Fundo

    Passo Fundo, Rio Grande do Sul, 99010-260, Brazil

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, 08041, Spain

  • Hôpital Lyon Sud

    Pierre-Bénite, 69310, France

  • I Can Oncology Center S.A. de C.V.

    Monterrey, Nuevo León, 64710, Mexico

  • ICO-Badalona Hospital Germans Trias i Pujol

    Badalona, Barcelona, 08916, Spain

  • IRCCS Ospedale Policlinico San Martino

    Genova, 16132, Italy

  • Instituto Alexander Fleming

    CABA, Buenos Aires, C1426ANZ, Argentina

  • Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA

    Rio de Janeiro, Rio de Janeiro, 20220-410, Brazil

  • Instituto de Oncologia do Paraná - IOP Matriz Mateus Leme

    Curitiba, Paraná, 80520-174, Brazil

  • Instituto de Oncologia do Paraná - IOP Oncoville

    Curitiba, Paraná, 82305-100, Brazil

  • Istanbul University Cerrahpasa Medical Faculty Hospital

    Istanbul, İ̇stanbul, 34098, Turkey (Türkiye)

  • Istituto Dermopatico dell'Immacolata (IDI-IRCCS)

    Roma, RM, 00167, Italy

  • Istituto Europeo di Oncologia IRCCS

    Milan, 20141, Italy

  • Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"

    Naples, 80131, Italy

  • Istituto Nazionale Tumori Regina Elena

    Roma, 00144, Italy

  • Istituto Oncologico Veneto IOV - IRCCS

    Padua, 35128, Italy

  • Istituto Tumori Giovanni Paolo II

    Bari, 70124, Italy

  • Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia

    Candiolo, Torino, 10060, Italy

  • Jagiellońskie Centrum Innowacji Sp. z o .o.

    Krakow, 30-348, Poland

  • Johannes Wesling Klinikum Minden

    Minden, North Rhine-Westphalia, 32429, Germany

  • Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház

    Szolnok, Jász-Nagykun-Szolnok, 5004, Hungary

  • KU Eye Center

    Prairie Village, Kansas, 66208, United States

  • Klinik und Poliklinik für Dermatologie und Allergologie

    München, Bavaria, 80337, Germany

  • Klinikum Nürnberg Nord

    Nuremberg, 90419, Germany

  • Laiko Hospital

    Athens, Attikí, 11527, Greece

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Medical Center Nadezhda Clinical EOOD

    Sofia, 1373, Bulgaria

  • Medizinische Hochschule Hannover

    Hanover, 30625, Germany

  • Medizinische Universität Graz

    Graz, 8036, Austria

  • Memorial Ankara Hastanesi

    Ankara, 06520, Turkey (Türkiye)

  • Narodny onkologicky ustav

    Bratislava, 833 10, Slovakia

  • Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

    Warsaw, 02-781, Poland

  • National Cancer Institute

    Kyiv, 03022, Ukraine

  • Nemocnica na okraji mesta, n.o.

    Partizánske, 95801, Slovakia

  • ONCARE Viaducto Nápoles

    Benito Juárez, Mexico City, 03810, Mexico

  • Olomouc University Hospital

    Olomouc, Olomoucký kraj, 779 00, Czechia

  • Onkologicky ustav sv. Alzbety, s.r.o.

    Bratislava, 812 50, Slovakia

  • Ophthalmic Consultants of Boston Inc (OCB)

    Boston, Massachusetts, 02114, United States

  • Orszagos Onkologiai Intezet

    Budapest, 1122, Hungary

  • Oslo universitetssykehus, Radiumhospitalet

    Oslo, 0379, Norway

  • POKO Poprad, s.r.o.

    Poprad, 058 01, Slovakia

  • Palmerston North Hospital

    Palmerston North, Manawatu, 4414, New Zealand

  • Preparaciones Oncológicas S.C.

    León, Guanajuato, 37178, Mexico

  • Private Medical Institution "Euromedservice"

    Pushkin, Sankt-Peterburg, 196603, Russia

  • Pécsi Tudományegyetem Klinikai Központ

    Pécs, Baranya, 7632, Hungary

  • SRH Wald-Klinikum Gera

    Gera, Thuringia, 07548, Germany

  • Sandton Oncology Medical Group (Pty) Ltd

    Johannesburg, Gauteng, 2196, South Africa

  • Sarah Cannon Research Institute

    Nashville, Tennessee, 37203, United States

  • Semmelweis Egyetem

    Budapest, 1085, Hungary

  • Soroka University Medical Center

    Beersheba, 8410101, Israel

  • St. Bartholomew's Hospital, Barts Health NHS Trust

    London, EC1A 7BE, United Kingdom

  • Szent-Gyorgyi Albert Klinikai Kozpont

    Szeged, 6720, Hungary

  • Szpital Kliniczny im. Heliodora Święcickiego UM w Poznaniu

    Poznan, 60-780, Poland

  • TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi

    Istanbul, İ̇stanbul, 34722, Turkey (Türkiye)

  • Tampereen yliopistollinen sairaala

    Tampere, Pirkanmaa, 33520, Finland

  • Tennessee Oncology, PLLC

    Nashville, Tennessee, 37203, United States

  • The South West Wales Cancer Institute, Swansea Bay University Health Board

    Swansea, SA2 8QA, United Kingdom

  • The University of Kansas Cancer Center

    Westwood, Kansas, 66205, United States

  • The University of Kansas Cancer Center - Investigational Drug Services

    Westwood, Kansas, 66205, United States

  • The University of Kansas Cancer Center - Overland Park

    Overland Park, Kansas, 66210, United States

  • The University of Kansas Clinical Research Center

    Fairway, Kansas, 66205, United States

  • Umhato Ead

    Sofia, 1756, Bulgaria

  • Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden

    Dresden, Saxony, 01307, Germany

  • Universitaetsklinikum Halle - Universitaetsklinik und Poliklinik fuer Dermatologie und Venerologie

    Halle, 06120, Germany

  • Universitaetsklinikum Hamburg-Eppendorf

    Hamburg, 20246, Germany

  • Universitaetsklinikum Schleswig-Holstein Campus Kiel

    Kiel, Schleswig-Holstein, 24105, Germany

  • Universitaetsklinikum Tuebingen

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • University Hospital Muenster

    Münster, 48149, Germany

  • University of Cincinnati Medical Center

    Cincinnati, Ohio, 45219, United States

  • University of Cincinnati Medical Center

    West Chester, Ohio, 45069, United States

  • University of Kansas Medical Center Research Institute

    Kansas City, Kansas, 66160, United States

  • University of Tennessee Medical Center

    Knoxville, Tennessee, 37920, United States

  • UniversitätsSpital Zürich

    Zürich Flughafen, 8058, Switzerland

  • Universitätsklinikum Bonn

    Bonn, North Rhine-Westphalia, 53127, Germany

  • Universitätsklinikum Essen (AöR)

    Essen, 45147, Germany

  • Universitätsklinikum Heidelberg

    Heidelberg, 69120, Germany

  • Universitätsklinikum Leipzig

    Leipzig, Saxony, 04103, Germany

  • Universitätsklinikum Regensburg

    Regensburg, 93053, Germany

  • Universitätsklinikum Schleswig-Holstein

    Lübeck, Schleswig-Holstein, 23538, Germany

  • Universitätsmedizin Johannes Gutenberg Universität Mainz

    Mainz, Rhineland-Palatinate, 55131, Germany

  • Vychodoslovensky onkologicky ustav, a.s.

    Košice, 04191, Slovakia

  • WCR Office

    Johannesburg, Gauteng, 2193, South Africa

  • Wits Clinical Research

    Johannesburg, Gauteng, 2193, South Africa

  • Zentrum fuer Radiologie und Nuklearmedizin am Johannisplatz

    Leipzig, 04103, Germany

Conditions

Explore the condition pages connected to this study.