Three-Drug attack on deadly skin cancer enters final testing phase
NCT ID NCT04657991
Summary
This study is testing if adding two oral drugs (encorafenib and binimetinib) to a standard immunotherapy (pembrolizumab) works better for people with advanced melanoma that has a specific BRAF gene mutation and hasn't been treated before. About 257 participants will be randomly assigned to receive either the three-drug combination or the standard drug plus a placebo. The main goal is to see if the combination is safe and more effective at shrinking tumors and controlling the cancer.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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A.O.U.S. Policlinico "Le Scotte"
Siena, SI, 53100, Italy
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AO di Perugia - Ospedale S. Maria della Misericordia, S.C Oncologia Medica
Perugia, 06132, Italy
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Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda EAD
Sofia, 1407, Bulgaria
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AdventHealth Hematology and Oncology
Orlando, Florida, 32804, United States
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AdventHealth Orlando
Orlando, Florida, 32804, United States
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AdventHealth Orlando Infusion Center
Orlando, Florida, 32804, United States
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AdventHealth Orlando, Investigational Drug Services
Orlando, Florida, 32804, United States
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Ars Medika Center, LLC
Kaliningrad, Russia
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Azienda Sanitaria Universitaria Friuli Centrale
Udine, Friuli Venezia Giulia, 33100, Italy
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BIH of Omsk Region "Clinical Oncological Dispensary"
Omsk, 644046, Russia
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BRCR Global Mexico - CDMX
Mexico City, 01120, Mexico
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Barts Health NHS Trust.
London, E1 1FR, United Kingdom
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CHU Grenoble Alpes
La Tronche, 38700, France
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CHU d'Amiens - Hôpital Nord
Amiens, 80054, France
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CHU de Poitiers
Poitiers, 86000, France
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CHUAC-Hospital Teresa Herrera
A Coruña, 15006, Spain
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CIUSSS du Saguenay-Lac-Saint-Jean
Chicoutimi, Quebec, G7H 5H6, Canada
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CNI KRC "Regional Cardiology Centre"
Kharkiv, 61166, Ukraine
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Charité Universitaetsmedizin Berlin - Campus Mitte
Berlin, 10117, Germany
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Clinica Viedma S. A
Viedma, Río Negro Province, 8500, Argentina
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Cliniques universitaires Saint-Luc
Brussels, 1200, Belgium
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Communal Noncommercial Enterprise of Lviv Regional Council "Lviv Oncological Regional Therapeutical
Lviv, 79031, Ukraine
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Complejo Hospitalario de Jaen
Jaén, 23007, Spain
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Complex Oncology Center - Plovdiv EOOD
Plovdiv, 4004, Bulgaria
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Debreceni Egyetem Klinikai Kozpont
Debrecen, 4032, Hungary
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Derzhavna ustanova Instytut zahalnoi ta nevidkladnoi khirurhii im.V.T.Zaitseva Natsionalnoi akademii
M. Kharkiv, 61103, Ukraine
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Drs Alberts Bouwer Jordaan
Pretoria, South Africa
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Drs Alberts, Bouwer and Jordaan Inc.
Pretoria, Gauteng, 0081, South Africa
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El Cielo Medical Center RSB, S.C
Puebla City, 72160, Mexico
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Eurocityclinic LLC
Saint Petersburg, 197022, Russia
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Fachklinik Hornheide
Münster, 48157, Germany
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Fakultni nemocnice Bulovka
Praha 8-Liben, 180 81, Czechia
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Fakultni nemocnice Ostrava
Ostrava-Poruba, 708 52, Czechia
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Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, MI, 20133, Italy
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Fundacion Instituto Valenciano de Oncologia
Valencia, 46009, Spain
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Fundação Pio XII - Hospital de Câncer de Barretos
Barretos, São Paulo, 14784-400, Brazil
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General Hospital of Athens "Laiko"
Athens, Attikí, 11527, Greece
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HELIOS Klinikum Erfurt
Erfurt, 99089, Germany
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Hadassah Medical Organization, Hadassah Medical Center, Ein-Karem
Jerusalem, 9112001, Israel
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Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)
Helsinki, 00029, Finland
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Hospital Clinic Barcelona
Barcelona, 08036, Spain
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Hospital Clinico Universitario Virgen de la Arrixaca
El Palmar, Murcia, 30120, Spain
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Hospital Regional Universitario de Malaga - Hospital Civil
Málaga, 29011, Spain
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Hospital Sírio-Libanês - Unidade Bela Vista
São Paulo, 01308-050, Brazil
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Hospital Universitari Vall D'Hebron, Servicio de Oncología Médica
Barcelona, 08035, Spain
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Hospital Universitario Arnau de Vilanova
Lleida, 25198, Spain
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Hospital Universitario Marqués de Valdecilla
Santander, Cantabria, 39008, Spain
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Hospital Universitario Miguel Servet
Zaragoza, 50009, Spain
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Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, Madrid, 28222, Spain
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Hospital Universitario Ramón y Cajal
Madrid, 28034, Spain
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Hospital Universitario Reina Sofía
Córdoba, 14004, Spain
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Hospital Universitario Virgen Macarena
Seville, 41009, Spain
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Hospital Universitario Virgen del Rocio
Seville, 41013, Spain
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Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
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Hospital de Clínicas de Passo Fundo
Passo Fundo, Rio Grande do Sul, 99010-260, Brazil
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Hospital de la Santa Creu i Sant Pau
Barcelona, 08041, Spain
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Hôpital Lyon Sud
Pierre-Bénite, 69310, France
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I Can Oncology Center S.A. de C.V.
Monterrey, Nuevo León, 64710, Mexico
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ICO-Badalona Hospital Germans Trias i Pujol
Badalona, Barcelona, 08916, Spain
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IRCCS Ospedale Policlinico San Martino
Genova, 16132, Italy
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Instituto Alexander Fleming
CABA, Buenos Aires, C1426ANZ, Argentina
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Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA
Rio de Janeiro, Rio de Janeiro, 20220-410, Brazil
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Instituto de Oncologia do Paraná - IOP Matriz Mateus Leme
Curitiba, Paraná, 80520-174, Brazil
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Instituto de Oncologia do Paraná - IOP Oncoville
Curitiba, Paraná, 82305-100, Brazil
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Istanbul University Cerrahpasa Medical Faculty Hospital
Istanbul, İ̇stanbul, 34098, Turkey (Türkiye)
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Istituto Dermopatico dell'Immacolata (IDI-IRCCS)
Roma, RM, 00167, Italy
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Istituto Europeo di Oncologia IRCCS
Milan, 20141, Italy
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Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
Naples, 80131, Italy
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Istituto Nazionale Tumori Regina Elena
Roma, 00144, Italy
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Istituto Oncologico Veneto IOV - IRCCS
Padua, 35128, Italy
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Istituto Tumori Giovanni Paolo II
Bari, 70124, Italy
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Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia
Candiolo, Torino, 10060, Italy
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Jagiellońskie Centrum Innowacji Sp. z o .o.
Krakow, 30-348, Poland
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Johannes Wesling Klinikum Minden
Minden, North Rhine-Westphalia, 32429, Germany
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Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház
Szolnok, Jász-Nagykun-Szolnok, 5004, Hungary
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KU Eye Center
Prairie Village, Kansas, 66208, United States
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Klinik und Poliklinik für Dermatologie und Allergologie
München, Bavaria, 80337, Germany
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Klinikum Nürnberg Nord
Nuremberg, 90419, Germany
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Laiko Hospital
Athens, Attikí, 11527, Greece
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Medical Center Nadezhda Clinical EOOD
Sofia, 1373, Bulgaria
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Medizinische Hochschule Hannover
Hanover, 30625, Germany
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Medizinische Universität Graz
Graz, 8036, Austria
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Memorial Ankara Hastanesi
Ankara, 06520, Turkey (Türkiye)
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Narodny onkologicky ustav
Bratislava, 833 10, Slovakia
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Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy
Warsaw, 02-781, Poland
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National Cancer Institute
Kyiv, 03022, Ukraine
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Nemocnica na okraji mesta, n.o.
Partizánske, 95801, Slovakia
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ONCARE Viaducto Nápoles
Benito Juárez, Mexico City, 03810, Mexico
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Olomouc University Hospital
Olomouc, Olomoucký kraj, 779 00, Czechia
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Onkologicky ustav sv. Alzbety, s.r.o.
Bratislava, 812 50, Slovakia
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Ophthalmic Consultants of Boston Inc (OCB)
Boston, Massachusetts, 02114, United States
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Orszagos Onkologiai Intezet
Budapest, 1122, Hungary
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Oslo universitetssykehus, Radiumhospitalet
Oslo, 0379, Norway
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POKO Poprad, s.r.o.
Poprad, 058 01, Slovakia
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Palmerston North Hospital
Palmerston North, Manawatu, 4414, New Zealand
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Preparaciones Oncológicas S.C.
León, Guanajuato, 37178, Mexico
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Private Medical Institution "Euromedservice"
Pushkin, Sankt-Peterburg, 196603, Russia
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Pécsi Tudományegyetem Klinikai Központ
Pécs, Baranya, 7632, Hungary
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SRH Wald-Klinikum Gera
Gera, Thuringia, 07548, Germany
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Sandton Oncology Medical Group (Pty) Ltd
Johannesburg, Gauteng, 2196, South Africa
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Sarah Cannon Research Institute
Nashville, Tennessee, 37203, United States
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Semmelweis Egyetem
Budapest, 1085, Hungary
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Soroka University Medical Center
Beersheba, 8410101, Israel
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St. Bartholomew's Hospital, Barts Health NHS Trust
London, EC1A 7BE, United Kingdom
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Szent-Gyorgyi Albert Klinikai Kozpont
Szeged, 6720, Hungary
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Szpital Kliniczny im. Heliodora Święcickiego UM w Poznaniu
Poznan, 60-780, Poland
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TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
Istanbul, İ̇stanbul, 34722, Turkey (Türkiye)
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Tampereen yliopistollinen sairaala
Tampere, Pirkanmaa, 33520, Finland
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Tennessee Oncology, PLLC
Nashville, Tennessee, 37203, United States
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The South West Wales Cancer Institute, Swansea Bay University Health Board
Swansea, SA2 8QA, United Kingdom
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The University of Kansas Cancer Center
Westwood, Kansas, 66205, United States
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The University of Kansas Cancer Center - Investigational Drug Services
Westwood, Kansas, 66205, United States
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The University of Kansas Cancer Center - Overland Park
Overland Park, Kansas, 66210, United States
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The University of Kansas Clinical Research Center
Fairway, Kansas, 66205, United States
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Umhato Ead
Sofia, 1756, Bulgaria
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Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden
Dresden, Saxony, 01307, Germany
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Universitaetsklinikum Halle - Universitaetsklinik und Poliklinik fuer Dermatologie und Venerologie
Halle, 06120, Germany
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Universitaetsklinikum Hamburg-Eppendorf
Hamburg, 20246, Germany
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Universitaetsklinikum Schleswig-Holstein Campus Kiel
Kiel, Schleswig-Holstein, 24105, Germany
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Universitaetsklinikum Tuebingen
Tübingen, Baden-Wurttemberg, 72076, Germany
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University Hospital Muenster
Münster, 48149, Germany
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University of Cincinnati Medical Center
Cincinnati, Ohio, 45219, United States
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University of Cincinnati Medical Center
West Chester, Ohio, 45069, United States
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University of Kansas Medical Center Research Institute
Kansas City, Kansas, 66160, United States
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University of Tennessee Medical Center
Knoxville, Tennessee, 37920, United States
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UniversitätsSpital Zürich
Zürich Flughafen, 8058, Switzerland
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Universitätsklinikum Bonn
Bonn, North Rhine-Westphalia, 53127, Germany
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Universitätsklinikum Essen (AöR)
Essen, 45147, Germany
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Universitätsklinikum Heidelberg
Heidelberg, 69120, Germany
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Universitätsklinikum Leipzig
Leipzig, Saxony, 04103, Germany
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Universitätsklinikum Regensburg
Regensburg, 93053, Germany
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Universitätsklinikum Schleswig-Holstein
Lübeck, Schleswig-Holstein, 23538, Germany
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Universitätsmedizin Johannes Gutenberg Universität Mainz
Mainz, Rhineland-Palatinate, 55131, Germany
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Vychodoslovensky onkologicky ustav, a.s.
Košice, 04191, Slovakia
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WCR Office
Johannesburg, Gauteng, 2193, South Africa
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Wits Clinical Research
Johannesburg, Gauteng, 2193, South Africa
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Zentrum fuer Radiologie und Nuklearmedizin am Johannisplatz
Leipzig, 04103, Germany
Conditions
Explore the condition pages connected to this study.