DNA-Guided prescribing may shield young cancer patients from harmful drug reactions

NCT ID NCT05667766

Ongoing Disease control Sponsor: Murdoch Childrens Research Institute Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial tests whether analyzing a child's DNA before prescribing supportive care drugs can lower the risk of serious side effects. Children with cancer or those receiving a bone marrow transplant are randomly assigned to get either standard care or prescribing guided by their genetic profile. The study tracks side effects and quality of life for up to a year to see if personalized medicine makes a real difference.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: whole genome sequencing with pharmacogenomic reporting
What this could lead to: If it works, this could make cancer treatment safer for children by tailoring drug choices to their DNA.
What could go wrong: The trial is relatively small and focuses on supportive care drugs, not the cancer treatment itself. Benefits may not apply to all children or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BONE MARROW TRANSPLANTATION NEOPLASMS

Contacts and locations

Locations

Perth Children's Hospital

Nedlands, Washington, 6009, Australia
Sydney Children's Hospital

Randwick, New South Wales, 2031, Australia
The Royal Children's Hospital

Parkville, Victoria, 3052, Australia
Women's and Children's Hospital

North Adelaide, South Australia, 5006, Australia

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