Weekly shot shows promise for adult growth hormone deficiency in Long-Term trial

NCT ID NCT05171855

Completed Disease control Sponsor: Ascendis Pharma Endocrinology Division A/S Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a once-weekly injection called lonapegsomatropin in 220 adults with growth hormone deficiency who had already completed a previous trial. The goal was to see if the drug remains safe and effective over a full year. Participants received the injection for 52 weeks, and researchers tracked side effects and changes in body fat and muscle mass.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

lonapegsomatropin (a once-weekly injection of a long-acting growth hormone)

What this could lead to

If successful, this could provide a convenient once-weekly treatment option for adults with growth hormone deficiency, potentially improving body composition and quality of life.

What could go wrong

This is an extension study, meaning participants already knew the drug was safe enough to continue. It is not a new breakthrough, and long-term risks or lack of efficacy remain possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

endocrine system disorder pituitary dwarfism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADULT GROWTH HORMONE DEFICIENCY ENDOCRINE SYSTEM DISEASES HORMONE DEFICIENCY

Contacts and locations

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Locations

Ascendis Pharma Investigational Site

Phoenix, Arizona, 85048, United States
Ascendis Pharma Investigational Site

Torrance, California, 90509, United States
Ascendis Pharma Investigational Site

Chicago, Illinois, 60611, United States
Ascendis Pharma Investigational Site

Indianapolis, Indiana, 46202, United States
Ascendis Pharma Investigational Site

Boston, Massachusetts, 02114, United States
Ascendis Pharma Investigational Site

Dearborn, Michigan, 48126, United States
Ascendis Pharma Investigational Site

Rochester, Minnesota, 55905, United States
Ascendis Pharma Investigational Site

St Louis, Missouri, 63110, United States
Ascendis Pharma Investigational Site

Las Vegas, Nevada, 89148, United States
Ascendis Pharma Investigational Site

Reno, Nevada, 89511, United States
Ascendis Pharma Investigational Site

New York, New York, 10017, United States
Ascendis Pharma Investigational Site

Portland, Oregon, 97239, United States
Ascendis Pharma Investigational Site

Dallas, Texas, 75390, United States
Ascendis Pharma Investigational Site

San Antonio, Texas, 78232, United States
Ascendis Pharma Investigational Site

Seattle, Washington, 98108, United States
Ascendis Pharma Investigational Site

Yerevan, 0075, Armenia
Ascendis Pharma Investigational Site

Saint Leonards, New South Wales, 2065, Australia
Ascendis Pharma Investigational Site

Sydney, New South Wales, 2109, Australia
Ascendis Pharma Investigational Site

Box Hill, Victoria, 3128, Australia
Ascendis Pharma Investigational Site

Fitzroy, Victoria, 3065, Australia
Ascendis Pharma Investigational Site

Parkville, Victoria, 3050, Australia
Ascendis Pharma Investigational Site

Perth, Western Australia, 6009, Australia
Ascendis Pharma Investigational Site

Halifax, Nova Scotia, B3H 1V7, Canada
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Lyon, 69677, France
Ascendis Pharma Investigational Site

Marseille, 13385, France
Ascendis Pharma Investigational Site

Nantes, 44093, France
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Tbilisi, 0144, Georgia
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Tbilisi, 0159, Georgia
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München, 80336, Germany
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Athens, 11527, Greece
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Thessaloniki, 54636, Greece
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Haifa, 31048, Israel
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Petah Tikva, 4941480, Israel
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Tel Aviv, 6423906, Israel
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Genova, 16132, Italy
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Rome, 00161, Italy
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Rome, 00168, Italy
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Kobe, Hyōgo, 650-0047, Japan
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Kawasaki, Kanagawa, 216-8511, Japan
Ascendis Pharma Investigational Site

Yokohama, Kanagawa, 222-0036, Japan
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Chiba, 260-8677, Japan
Ascendis Pharma Investigational Site

Fukuoka, 812-8582, Japan
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Ishikawa, 920-0293, Japan
Ascendis Pharma Investigational Site

Kagoshima, 890-8520, Japan
Ascendis Pharma Investigational Site

Kawasaki, 210-0024, Japan
Ascendis Pharma Investigational Site

Kawasaki, 211-8533, Japan
Ascendis Pharma Investigational Site

Kitakyushu, 807-8555, Japan
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Matsumoto, 390-8510, Japan
Ascendis Pharma Investigational Site

Miyakojima, 534-0021, Japan
Ascendis Pharma Investigational Site

Nagakute, 480-1195, Japan
Ascendis Pharma Investigational Site

Nara, 634-8522, Japan
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Okayama, 700-8558, Japan
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Osaka, 550-0006, Japan
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Shizuoka, 422-8527, Japan
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Suita, 565-0871, Japan
Ascendis Pharma Investigational Site

Yamagata, 990-9585, Japan
Ascendis Pharma Investigational Site

Yokohama, 236-0004, Japan
Ascendis Pharma Investigational Site

George Town, 10450, Malaysia
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Malacca, 75400, Malaysia
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Putrajaya, 62250, Malaysia
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Krakow, 31-501, Poland
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Lodz, 93-338, Poland
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Warsaw, 03-242, Poland
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Wroclaw, 50-367, Poland
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Bucharest, 11868, Romania
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Iași, 700106, Romania
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Belgrade, 11000, Serbia
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Bratislava, 82606, Slovakia
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Ľubochňa, 3491, Slovakia
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Soeul, 06591, South Korea
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Alicante, 3010, Spain
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Barcelona, 8035, Spain
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Barcelona, 8041, Spain
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Seville, 41013, Spain
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Ankara, 06560, Turkey (Türkiye)
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Antalya, 07070, Turkey (Türkiye)
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Aydin, 09010, Turkey (Türkiye)
Ascendis Pharma Investigational Site

İzmit, 41001, Turkey (Türkiye)
Ascendis Pharma Investigational Site

Kayseri, 38039, Turkey (Türkiye)
Ascendis Pharma Investigational Site

Ivano-Frankivsk, 76008, Ukraine
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Kyiv, 03115, Ukraine
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Kyiv, 04001, Ukraine
Ascendis Pharma Investigational Site

Kyiv, 04114, Ukraine
Ascendis Pharma Investigational Site

Vinnytsia, 21010, Ukraine
Ascendis Pharma Investigational Site

Leeds, LS9 7TF, United Kingdom