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Kids' brain tumor drug combo gets Long-Term safety check

NCT ID NCT03975829

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 31 times

Summary

This study follows children who previously took dabrafenib and/or trametinib for certain brain tumors. It aims to see how safe these drugs are over the long term by tracking side effects and monitoring growth. About 163 children are enrolled, and the study is no longer recruiting new participants.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Childrens National Hospital

    ACTIVE_NOT_RECRUITING

    Washington D.C., District of Columbia, 20010, United States

  • Cinn Children Hosp Medical Center

    ACTIVE_NOT_RECRUITING

    Cincinnati, Ohio, 45206, United States

  • Dana Farber Cancer Institute

    ACTIVE_NOT_RECRUITING

    Boston, Massachusetts, 02215, United States

  • Indiana Uni School of Medicine

    ACTIVE_NOT_RECRUITING

    Indianapolis, Indiana, 46202-2810, United States

  • Johns Hopkins Hospital

    ACTIVE_NOT_RECRUITING

    Baltimore, Maryland, 21287, United States

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Memorial Sloan Kettering Cancer Ctr

    ACTIVE_NOT_RECRUITING

    New York, New York, 10065, United States

  • Nicklaus Childrens Hospital

    ACTIVE_NOT_RECRUITING

    Miami, Florida, 33155, United States

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    CABA, Buenos Aires, C1428AQK, Argentina

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Darlinghurst, New South Wales, 2010, Australia

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Parkville, Victoria, 3052, Australia

  • Novartis Investigative Site

    COMPLETED

    Brussels, 1200, Belgium

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Barretos, São Paulo, 14784 400, Brazil

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    São Paulo, São Paulo, 04829-310, Brazil

  • Novartis Investigative Site

    COMPLETED

    São Paulo, São Paulo, 08270-070, Brazil

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Vancouver, British Columbia, V6H 3V4, Canada

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Toronto, Ontario, M5G 1X8, Canada

  • Novartis Investigative Site

    COMPLETED

    Montreal, Quebec, H3T 1C5, Canada

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Brno, 625 00, Czechia

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Prague, 150 06, Czechia

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Copenhagen, DK-2100, Denmark

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Tampere, 33521, Finland

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Rennes, Brittany Region, 35203, France

  • Novartis Investigative Site

    COMPLETED

    Brest, 29609, France

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Marseille, 13885, France

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Paris, 75231, France

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Rennes, 35033, France

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Vandœuvre-lès-Nancy, 54511, France

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Villejuif, 94800, France

  • Novartis Investigative Site

    RECRUITING

    Cologne, North Rhine-Westphalia, 50937, Germany

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Augsburg, 86179, Germany

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Berlin, 13353, Germany

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Essen, 45147, Germany

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Hamburg, 20246, Germany

  • Novartis Investigative Site

    RECRUITING

    Petah Tikva, 4920235, Israel

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Florence, FI, 50139, Italy

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Genova, GE, 16147, Italy

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Milan, MI, 20133, Italy

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Roma, RM, 00165, Italy

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Torino, TO, 10126, Italy

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Setagaya-ku, Tokyo, 1578535, Japan

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Osaka, 5340021, Japan

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Utrecht, 3584 CS, Netherlands

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Moscow, 117198, Russia

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Madrid, 28009, Spain

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Valencia, 46026, Spain

  • Novartis Investigative Site

    COMPLETED

    Stockholm, 17176, Sweden

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Sutton, Surrey, SM2 5PT, United Kingdom

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Liverpool, L12 2AP, United Kingdom

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    London, NW1 2BU, United Kingdom

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    London, WC1N 3JH, United Kingdom

  • Phoenix Children s Hospital

    ACTIVE_NOT_RECRUITING

    Phoenix, Arizona, 85016, United States

  • St Jude Childrens Research Hospital

    ACTIVE_NOT_RECRUITING

    Memphis, Tennessee, 38105, United States

  • Texas Childrens Hospital

    COMPLETED

    Houston, Texas, 77030, United States

  • University of Minnesota

    ACTIVE_NOT_RECRUITING

    Minneapolis, Minnesota, 55455, United States

Conditions

Explore the condition pages connected to this study.

ANAPLASTIC ASTROCYTOMA ANAPLASTIC GANGLIOGLIOMA ANAPLASTIC OLIGODENDROGLIOMA ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA ANGIOCENTRIC GLIOMA ANGIOCENTRIC GLIOMA ASTROCYTOMA CENTRAL NEUROCYTOMA CEREBELLAR LIPONEUROCYTOMA CHORDOID GLIOMA OF THIRD VENTRICLE DESMOPLASTIC INFANTILE ASTROCYTOMA AND GANGLIOGLIOMA DIFFUSE ASTROCYTOMA DYSPLASTIC GANGLIOCYTOMA OF CEREBRELLUM EXTRAVENTRICULAR NEUROCYTOMA GANGLIOCYTOMA GANGLIOGLIOMA GIANT CELL ASTROCYTOMA GIANT CELL ASTROCYTOMA GLIOBLASTOMA GLIOBLASTOMA NEUROFIBROMATOSIS TYPE 1 OLIGODENDROGLIOMA, CHILDHOOD PAPILLARY GLIONEURONAL TUMOR PILOCYTIC ASTROCYTOMA PLEOMORPHIC XANTHOASTROCYTOMA ROSETTE-FORMING GLIONEURONAL TUMOR