New antibody combo trial aims to calm severe colitis without daily pills

NCT ID NCT07012395

Recruiting now Disease control Sponsor: Spyre Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 11, 2026 · Updated 24 times

Summary

This study tests whether long-acting antibodies, given alone or together, can safely reduce inflammation and improve symptoms in adults with moderate-to-severe ulcerative colitis. About 645 participants will receive the treatment through an IV infusion followed by regular shots. The goal is to see if these antibodies can help achieve remission and heal the gut lining.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

029
RECRUITING

Miami, Florida, 33165, United States

Contact
040
RECRUITING

Chapel Hill, North Carolina, 27599, United States

Contact
Site 002
RECRUITING

San Antonio, Texas, 78229, United States

Contact
Site 003
RECRUITING

Boston, Massachusetts, 02114, United States

Contact
Site 005
RECRUITING

Garland, Texas, 75246, United States

Contact
Site 006
RECRUITING

Kansas City, Kansas, 66160, United States

Contact
Site 007
RECRUITING

Kissimmee, Florida, 34741, United States

Contact
Site 008
RECRUITING

Southlake, Texas, 76092, United States

Contact
Site 009
RECRUITING

Webster, Texas, 77598, United States

Contact
Site 011
RECRUITING

Glen Burnie, Maryland, 21061, United States

Contact
Site 012
RECRUITING

Lancaster, California, 93534, United States

Contact
Site 013
RECRUITING

Cedar Park, Texas, 78613, United States

Contact
Site 016
RECRUITING

Winston-Salem, North Carolina, 27103, United States

Contact
Site 017
RECRUITING

Kingsport, Tennessee, 37663, United States

Contact
Site 019
RECRUITING

Tacoma, Washington, 98405, United States

Contact
Site 023
RECRUITING

La Jolla, California, 92037, United States

Contact
Site 024
RECRUITING

Canoga Park, California, 91304, United States

Contact
Site 025
RECRUITING

Providence, Rhode Island, 02904, United States

Contact
Site 028
RECRUITING

Rochester, Minnesota, 55905, United States

Contact
Site 033
RECRUITING

Colorado Springs, Colorado, 91304, United States

Contact
Site 035
RECRUITING

Marrero, Louisiana, 70072, United States

Contact
Site 037
RECRUITING

New York, New York, 10065, United States

Contact
Site 041
RECRUITING

Durham, North Carolina, 27710, United States

Contact
Site 083
RECRUITING

London, Ontario, G8H 3P7, Canada

Contact
Site 085
RECRUITING

Greater Sudbury, P3C1X3, Canada

Contact
Site 086
RECRUITING

London, N6K 1M6, Canada

Contact
Site 202
RECRUITING

Heidelberg, 3084, Australia

Contact
Site 203
RECRUITING

Melbourne, 3004, Australia

Contact
Site 204
RECRUITING

Liverpool, 2170, Australia

Contact
Site 206
RECRUITING

South Brisbane, 4101, Australia

Contact
Site 207
RECRUITING

Woolloongabba, 4102, Australia

Contact
Site 208
RECRUITING

Concord, 2139, Australia

Contact
Site 265
RECRUITING

Sūrat, 395002, India

Contact
Site 266
RECRUITING

Kochi, 682040, India

Contact
Site 268
RECRUITING

Jaipur, 302004, India

Contact
Site 270
RECRUITING

Hyderabad, 500032, India

Contact
Site 285
RECRUITING

Sendai, 981-3213, Japan

Contact
Site 286
RECRUITING

Saga, 849-8501, Japan

Contact
Site 291
RECRUITING

Kobe, 650-0015, Japan

Contact
Site 293
RECRUITING

Urayasu-shi, 279-0021, Japan

Contact
Site 351
RECRUITING

Seoul, 03722, South Korea

Contact
Site 352
RECRUITING

Seoul, 06591, South Korea

Contact
Site 353
RECRUITING

Wŏnju, 26426, South Korea

Contact
Site 354
RECRUITING

Daegu, 40404, South Korea

Contact
Site 355
RECRUITING

Daejeon, 34943, South Korea

Contact Phone: •••-•••-••••
Site 356
RECRUITING

Seoul, 03312, South Korea

Contact
Site 357
RECRUITING

Busan, 48108, South Korea

Contact
Site 358
RECRUITING

Daegu, 42415, South Korea

Contact
Site 359
RECRUITING

Suwon, 16247, South Korea

Contact
Site 360
RECRUITING

Seoul, 07985, South Korea

Contact
Site 361
RECRUITING

Daegu, 42601, South Korea

Contact
Site 362
RECRUITING

Seoul, 6351, South Korea

Contact Phone: •••-•••-••••
Site 391
RECRUITING

Taipei, 100225, Taiwan

Contact
Site 392
RECRUITING

Chiayi City, 600, Taiwan

Contact
Site 393
RECRUITING

Taoyuan City, 333, Taiwan

Contact
Site 394
RECRUITING

Changhua, 500, Taiwan

Contact
Site 396
RECRUITING

Taichung, 404327, Taiwan

Contact
Site 397
RECRUITING

Taipei, 104, Taiwan

Contact
Site 421
RECRUITING

Amman, 11942, Jordan

Contact
Site 422
RECRUITING

Irbid, 21110, Jordan

Contact
Site 424
RECRUITING

Amman, 11196, Jordan

Contact
Site 441
RECRUITING

Beersheba, 8410101, Israel

Contact
Site 442
RECRUITING

Nahariya, 2210001, Israel

Contact
Site 443
RECRUITING

Haifa, 31048, Israel

Contact
Site 444
RECRUITING

Jerusalem, 9103102, Israel

Contact
Site 445
RECRUITING

Beer Yaaqov, 7033001, Israel

Contact
Site 446
RECRUITING

Jerusalem, 9112001, Israel

Contact
Site 463
RECRUITING

Linz, 4021, Austria

Contact
Site 471
RECRUITING

Ghent, 9000, Belgium

Contact
Site 472
RECRUITING

Roeselare, 9000, Belgium

Contact
Site 475
RECRUITING

Bruges, 8310, Belgium

Contact
Site 481
RECRUITING

Banja Luka, 78 000, Bosnia and Herzegovina

Contact
Site 483
RECRUITING

Sarajevo, 71000, Bosnia and Herzegovina

Contact Phone: •••-•••-••••
Site 484
RECRUITING

Mostar, 88000, Bosnia and Herzegovina

Contact
Site 492
RECRUITING

Sofia, 1343, Bulgaria

Contact
Site 494
RECRUITING

Gorna Oryahovitsa, 5100, Bulgaria

Contact
Site 495
RECRUITING

Sofia, 1463, Bulgaria

Contact
Site 498
RECRUITING

Rousse, 7002, Bulgaria

Contact
Site 531
RECRUITING

Brno, 615 00, Czechia

Contact
Site 534
RECRUITING

Ostrava, 702 00, Czechia

Contact
Site 536
RECRUITING

Klatovy, 33901, Czechia

Contact
Site 538
RECRUITING

Prague, 150 00, Czechia

Contact
Site 551
RECRUITING

Nantes, 44300, France

Contact
Site 556
RECRUITING

Pierre-Bénite, 69310, France

Contact
Site 557
RECRUITING

Nice, 06200, France

Contact
Site 558
RECRUITING

Saint-Etienne, 42270, France

Contact
Site 581
RECRUITING

Tbilisi, 0102, Georgia

Contact Phone: •••-•••-••••
Site 582
RECRUITING

Tbilisi, 0159, Georgia

Contact Phone: •••-•••-••••
Site 583
RECRUITING

Tbilisi, 01444, Georgia

Contact Phone: •••-•••-••••
Site 584
RECRUITING

Kutaisi, 4600, Georgia

Contact Phone: •••-•••-••••
Site 585
RECRUITING

Tbilisi, 0180, Georgia

Contact Phone: •••-•••-••••
Site 586
RECRUITING

Tbilisi, 0144, Georgia

Contact Phone: •••-•••-••••
Site 587
RECRUITING

Tbilisi, 0159, Georgia

Contact Phone: •••-•••-••••
Site 588
RECRUITING

Tbilisi, 0114, Georgia

Contact Phone: •••-•••-••••
Site 589
RECRUITING

Marneuli, 3000, Georgia

Contact Phone: •••-•••-••••
Site 590
RECRUITING

Tbilisi, 0178, Georgia

Contact Phone: •••-•••-••••
Site 603
RECRUITING

Ulm, 89081, Germany

Contact
Site 604
RECRUITING

Berlin, 14163, Germany

Contact
Site 606
RECRUITING

Berlin, 10117, Germany

Contact
Site 607
RECRUITING

Dachau, 85221, Germany

Contact
Site 609
RECRUITING

Munich, 81377, Germany

Contact
Site 611
RECRUITING

Brandenburg an der Havel, 14770, Germany

Contact
Site 631
RECRUITING

Chaïdári, 124 62, Greece

Contact
Site 632
RECRUITING

Athens, 115 27, Greece

Contact
Site 634
RECRUITING

Athens, 10676, Greece

Contact
Site 635
RECRUITING

Athens, Attica, 11527, Greece

Contact
Site 651
RECRUITING

Budapest, H-1088, Hungary

Contact
Site 652
RECRUITING

Székesfehérvár, H-8000, Hungary

Contact
Site 654
RECRUITING

Békéscsaba, H-5600, Hungary

Contact
Site 655
RECRUITING

Budapest, H-1062, Hungary

Contact
Site 656
RECRUITING

Budapest, H-1083, Hungary

Contact
Site 671
RECRUITING

Segrate, Milan, 20132, Italy

Contact
Site 672
RECRUITING

Negrar, 37024, Italy

Contact
Site 674
RECRUITING

Rozzano, Milan, 20089, Italy
Site 675
RECRUITING

Turin, 10128, Italy

Contact
Site 676
RECRUITING

San Donato Milanese, Milan, 20097, Italy

Contact
Site 677
RECRUITING

Padova, 35128, Italy

Contact
Site 681
RECRUITING

Rome, 00168, Italy

Contact
Site 682
RECRUITING

Castellana Grotte, Bari, 70013, Italy

Contact
Site 703
RECRUITING

Vilnius, LT-08406, Lithuania

Contact
Site 711
RECRUITING

Chisinau, MD2025, Moldova

Contact Phone: •••-•••-••••
Site 712
RECRUITING

Chisinau, MD2025, Moldova

Contact Phone: •••-•••-••••
Site 713
RECRUITING

Chisinau, MD2005, Moldova

Contact Phone: •••-•••-••••
Site 714
RECRUITING

Chisinau, MD2025, Moldova

Contact Phone: •••-•••-••••
Site 715
RECRUITING

Chisinau, MD2068, Moldova

Contact Phone: •••-•••-••••
Site 731
RECRUITING

Warsaw, 04-501, Poland

Contact
Site 732
RECRUITING

Bydgoszcz, 85-794, Poland

Contact
Site 733
RECRUITING

Szczecin, 71-685, Poland

Contact
Site 734
RECRUITING

Wroclaw, 53-149, Poland

Contact
Site 735
RECRUITING

Katowice, 40-748, Poland

Contact
Site 736
RECRUITING

Rzeszów, 35-326, Poland

Contact
Site 737
RECRUITING

Szczecin, 71-434, Poland

Contact
Site 738
RECRUITING

Wroclaw, 52-416, Poland

Contact
Site 739
RECRUITING

Warsaw, 00--710, Poland

Contact
Site 740
RECRUITING

Poznan, 60-309, Poland

Contact
Site 741
RECRUITING

Warsaw, 02-786, Poland

Contact
Site 742
RECRUITING

Wroclaw, 54-239, Poland

Contact
Site 743
RECRUITING

Opole, 45-819, Poland

Contact
Site 744
RECRUITING

Sopot, 81-756, Poland

Contact
Site 745
RECRUITING

Staszów, 28-2200, Poland

Contact
Site 747
RECRUITING

Wroclaw, 53-611, Poland

Contact
Site 748
RECRUITING

Krakow, 31-501, Poland

Contact
Site 749
RECRUITING

Katowice, 40-600, Poland

Contact
Site 750
RECRUITING

Warsaw, 57-300, Poland

Contact
Site 751
RECRUITING

Warsaw, 00-189, Poland

Contact
Site 752
RECRUITING

Tychy, 43-100, Poland

Contact
Site 753
RECRUITING

Bydgoszcz, 85-2299, Poland

Contact
Site 754
RECRUITING

Warsaw, 02-172, Poland

Contact
Site 781
RECRUITING

Bucharest, 020125, Romania

Contact
Site 783
RECRUITING

Bucharest, 011273, Romania

Contact
Site 784
RECRUITING

Bucharest, 014142, Romania

Contact
Site 786
RECRUITING

Constanța, 900161, Romania

Contact
Site 788
RECRUITING

Timișoara, 300239, Romania

Contact
Site 801
RECRUITING

Zrenjanin, 23000, Serbia

Contact Phone: •••-•••-••••
Site 802
RECRUITING

Belgrade, 11000, Serbia

Contact Phone: •••-•••-••••
Site 803
RECRUITING

Belgrade, 11080, Serbia

Contact Phone: •••-•••-••••
Site 805
RECRUITING

Niš, 18 000, Serbia

Contact
Site 806
RECRUITING

Užice, 31000, Serbia

Contact Phone: •••-•••-••••
Site 807
RECRUITING

Belgrade, 11000, Serbia

Contact Phone: •••-•••-••••
Site 821
RECRUITING

Prešov, 080 01, Slovakia

Contact
Site 822
RECRUITING

Košice, 040 13, Slovakia

Contact
Site 823
RECRUITING

Bratislava, 811 09, Slovakia

Contact
Site 825
RECRUITING

Zvolen, 960 01, Slovakia

Contact
Site 832
RECRUITING

Santiago de Compostela, A Coruna, 15702, Spain

Contact
Site 834
RECRUITING

Madrid, 28031, Spain

Contact
Site 835
RECRUITING

Gijón, 33394, Spain

Contact
Site 836
RECRUITING

Ourense, 32005, Spain

Contact
Site 837
RECRUITING

Madrid, 28222, Spain

Contact
Site 838
RECRUITING

Lugo, 27003, Spain

Contact
Site 851
RECRUITING

Sankt Gallen, 9007, Switzerland

Contact
Site 852
RECRUITING

Basel, 4031, Switzerland

Contact
Site 853
RECRUITING

Bern, 3012, Switzerland

Contact
Site 861
RECRUITING

Mersin, 33110, Turkey (Türkiye)

Contact
Site 862
RECRUITING

Trabzon, 61080, Turkey (Türkiye)

Contact
Site 865
RECRUITING

Sanliurfa, 63290, Turkey (Türkiye)

Contact
Site 866
RECRUITING

Kocaeli, 41380, Turkey (Türkiye)

Contact
Site 901
RECRUITING

Lutsk, 43005, Ukraine

Contact Phone: •••-•••-••••
Site 902
RECRUITING

Kyiv, 02002, Ukraine

Contact Phone: •••-•••-••••
Site 903
RECRUITING

Kyiv, 04210, Ukraine

Contact Phone: •••-•••-••••
Site 904
RECRUITING

Kyiv, 02091, Ukraine

Contact Phone: •••-•••-••••
Site 905
RECRUITING

Kyiv, 03037, Ukraine

Contact Phone: •••-•••-••••
Site 906
RECRUITING

Ivano-Frankivsk, 76008, Ukraine

Contact Phone: •••-•••-••••
Site 907
RECRUITING

Vinnytsia, 21029, Ukraine

Contact Phone: •••-•••-••••
Site 908
RECRUITING

Vinnytsia, 21009, Ukraine

Contact Phone: •••-•••-••••
Site 909
RECRUITING

Lviv, 79010, Ukraine

Contact Phone: •••-•••-••••
Site 910
RECRUITING

Vinnytsia, 21028, Ukraine

Contact
Site 911
RECRUITING

Kyiv, 04107, Ukraine

Contact Phone: •••-•••-••••
Site 912
RECRUITING

Lviv, 79059, Ukraine

Contact
Site 913
RECRUITING

Kyiv, 04050, Ukraine

Contact Phone: •••-•••-••••
Site 914
RECRUITING

Poltava, 36011, Ukraine

Contact Phone: •••-•••-••••
Trial Site 804
RECRUITING

Belgrade, 11 000, Serbia

Contact

Conditions

Explore the condition pages connected to this study.

COLITIS COLITIS, ULCERATIVE INFLAMMATORY BOWEL DISEASES INFLAMMATORY BOWEL DISEASES ULCERATIVE COLITIS ULCERATIVE COLITIS