Heart drug shows promise for liver health in kids with rare heart condition
NCT ID NCT03430583
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether the drug udenafil can reduce liver stiffness in 88 children with single ventricle heart disease, a condition where the heart has only one pumping chamber. Participants took udenafil twice daily for 52 weeks, and liver stiffness was measured using ultrasound and MRI. The goal was to see if the drug could help prevent liver damage, a common long-term complication in these children.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Udenafil
- What this could lead to
- If successful, udenafil could help reduce liver stiffness in children with single ventricle heart disease, potentially lowering the risk of liver damage over time.
- What could go wrong
- This is a small, completed phase 3 study with only 88 participants. Results may not apply to all patients, and udenafil may cause side effects like headache or flushing. The drug is not a cure and does not replace standard heart care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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Children's Healthcare of Atlanta
Atlanta, Georgia, 30322, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Children's Hospital of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Children's Mercy Hospital
Kansas City, Kansas, 64108, United States
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Children's Mercy Hospital Kansas City
Kansas City, Missouri, 64108, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20008, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Nemours Cardiac Center/Alfred I. duPont Hospital for Children
Wilmington, Delaware, 19803, United States
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Primary Children's Medical Hospital/Dept. of Pediatric Cardiology
Salt Lake City, Utah, 84113, United States
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Texas Children's Hospital
Houston, Texas, 77030, United States
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The Hospital for Sick Children
Toronto, Ontario, ON M5G 1X8, Canada
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University of Michigan Congenital Heart Center
Ann Arbor, Michigan, 48109-4204, United States
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University of Nebraska Children's Hospital and Medical Center
Omaha, Nebraska, 68114, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
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