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Freezing or vitamin c: two Non-Surgical bets to fade dark gums

NCT ID NCT07810101

Symptom relief Sponsor: Al-Azhar University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 10, 2026 · Updated 1 time

Summary

Researchers at Al-Azhar University are comparing two non-surgical methods, topical liquid nitrogen and topical ascorbic acid (vitamin C), against standard surgery for treating dark gum pigmentation. The trial enrolls 30 adults aged 18 to 40 with mild to severe pigmentation on the front upper and lower gums. The team measures how much the gum color lightens using a standard pigmentation index and examines gum tissue samples to see how the treatments affect melanin-producing cells.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
liquid nitrogen and ascorbic acid applied to the gums
What this could lead to
If either topical approach works, it could offer a simpler, less invasive way to lighten dark gums without surgery.
What could go wrong
This is a small, single-center study of 30 people, so results may not apply broadly. Liquid nitrogen can irritate or damage gum tissue, and pigmentation sometimes returns after treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals with mild-to-severe anterior melanin gingival pigmentation in the anterior portion of the upper and lower gingiva according to Dummet's classification will be involved. * The patients included in this study will be Type 1 individuals according to American Society of Anesthesiology . * The age of the patients ranges between 18 and 40 years. Exclusion Criteria: * smoker patients * pregnant and lactating women * patients with any systemic disease that may induce the production of melanin * patients with periodontal disease, non vital anterior teeth * patients with known hypersensitivity to ascorbic acid * patients who had previous depigmentation procedures.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingiival hyperpigmentation Gingival pigmentation

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

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Contacts and locations

Locations

  • Faculty of dental medicine, Alazhar university, Assiut branch

    Asyut, Asyut Governorate, 71511, Egypt

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