A blood test clue to unmask lipedema?
NCT ID NCT07787234
First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time
Summary
This study asks whether standard blood-based inflammation markers can distinguish lipedema from ordinary obesity and reflect how severe the condition is. Researchers will compare these markers in women with lipedema, women with obesity matched by body mass index, and healthy controls. No new treatments or invasive tests are involved—only existing lab data and, for lipedema patients, ultrasound and symptom questionnaires.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If certain inflammation markers prove higher in lipedema and track with severity, they could become simple blood tests to help diagnose and monitor the condition.
- What could go wrong
- This is an observational study using existing lab data, so it cannot prove cause and effect. The markers may overlap with obesity-related inflammation, limiting their distinct usefulness.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
192 people
The number who actually took part.
- Started
-
Jun 2026
- Finished
-
Aug 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population consists of adult female patients who presented to our hospital's Physical Medicine and Rehabilitation outpatient clinic and were clinically diagnosed with lipedema. The control group will consist of healthy female individuals evaluated at the same center who do not have a diagnosis of lipedema or lymphedema and have similar age characteristics. Sample size analysis will be performed using the G\*Power 3.1 program. Since the primary endpoint of the study is defined as the difference in SII between the lipedema and control groups, the comparison of the means of three independent groups will be the basis. In a two-tailed analysis, with Cohen's d = 0.60 effect size, alpha error level 0.05, and power 80%, 64 participants per group, totaling 192 participants, are required.
- Ages
-
18 to 65 years
- Sex
-
Female participants only
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1\. Inclusion Criteria (Patient Group) 1. Diagnosis of lipedema 2. Female patients aged 18-65 years 3. Literacy 4. Signing the informed consent form to participate in the study 2\. Inclusion Criteria (Obese-Overweight Control Group) 1. Female patients aged 18-65 years 2. Age and BMI matched with patients with lipedema 3. Literacy 4. Signing the informed consent form to participate in the study 3\. Inclusion criteria (healthy control group) 1. Being female, aged 18-65 2. BMI \<25 3. Being literate 4. Having signed the informed consent form by agreeing to participate in the study Exclusion Criteria: 1. Being under 18 or over 65 years of age 2. Acute infection, autoimmune/rheumatological disease, malignancy, hematological disease, receiving steroid/immunosuppressive treatment 3. Pregnancy 4. Peripheral artery disease 5. Severe cardiopulmonary failure (stage 3-4) 6. Systemic diseases such as uncontrolled hypertension and diabetes 7. Presence of cognitive impairment, hearing loss, communication difficulties that would hinder understanding of questionnaires and protocols
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Inflamation are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Department of Physical Medicine and Rehabilitation, Health Sciences University Sultan Abdulhamid Han Training and Research Hospital
Istanbul, Uskudar, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Effects of adjunct Omega-3 long-chain polyunsaturated fatty acids in pulmonary tuberculosis patients: an early bactericidal activity and inflammatory activity trial
- Real-World effectiveness, safety, and Patient-Reported outcomes of tirzepatide in adults with type 2 diabetes mellitus, obesity, or prediabetes in pakistan: a multicentre, prospective, observational cohort study
- Combined inspiratory muscle training and functional High-Intensity interval training promote respiratory, diaphragmatic, and aerobic adaptations in children with obesity
- Relationship between Collagen-Containing supplement use and muscle mass and body image following metabolic and bariatric surgery: a prospective observational study
- Can a dash of spice and protein shield muscle during Weight-Loss shots?
- Can loose joints worsen lipedema pain? researchers investigate