Malaria drug may boost cancer immunotherapy in advanced melanoma trial

NCT ID NCT04464759

First seen May 13, 2026 · Last updated May 14, 2026 · Updated 1 time

Summary

This study tests whether adding hydroxychloroquine (a malaria drug) to standard immunotherapy (nivolumab with or without ipilimumab) can safely improve treatment for advanced melanoma that has spread. About 94 adults with stage III or IV melanoma will take part. The goal is to find the best dose and see if the combination shrinks tumors better than immunotherapy alone.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Abramson Cancer Center at University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.