Scientists hunt for clues to why lichen planus treatment fails
NCT ID NCT05330572
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study follows 110 adults with lichen planus who are using topical steroids, the standard first treatment. Researchers will collect clinical details, saliva, blood, and tissue samples to identify factors linked to poor response. The goal is to understand why some patients don't improve, which could lead to better, personalized treatments in the future.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors predict which patients will benefit from topical steroids and lead to more personalized treatments for lichen planus.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't directly improve care. Results may not apply to all patients, and the factors identified may not lead to new treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 110 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2022
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
All participants will be selected from attendants of the Oral \& Maxillofacial Unit, Women's Day Clinic and Aberdeen Dental School in the Foresterhill Campus. Patients diagnosed with oral or vulvovaginal lichen planus will be recruited into the study, only following biopsy confirmation. The diagnosis of lichen planus will be made on the basis of accepted clinical and histopathological findings to meet the eligibility criteria. Patients who have been advised to use topical steroid therapy as a part of their management plan for lichen planus.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients aged more than 18 years, with confirmed histopathological diagnosis of lichen planus and undergoing topical steroid therapy. * Participants who have the capacity to consent. * Participants who show a willingness to attend an initial appointment and a follow-up post-treatment appointment. Exclusion Criteria: * Patients on systemic steroids and other immunosuppressive agents for the treatment of lichen planus * Cases of graft versus host disease or those suffering from other systemic inflammatory conditions mimicking lichen planus (e.g. connective tissue disease). * Pregnant and lactating participants. * Inability to consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Aberdeen Dental School
Aberdeen, AB25 2ZR, United Kingdom
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University of Aberdeen
Aberdeen, Aberdeen, Scotland, AB24 3FX, United Kingdom
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