New MRI scans aim to catch cancers before they grow in High-Risk families

NCT ID NCT03176836

ENROLLING_BY_INVITATION Diagnosis Sponsor: The Hospital for Sick Children Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

Li-Fraumeni syndrome is a rare genetic condition that greatly increases the risk of developing many types of cancer. This pilot study will test three advanced MRI techniques—whole body STIR MRI, DW-MRI, and PET-MRI—in 30 people with the condition to see how well they can detect very small tumors and tell them apart from harmless growths. The goal is to improve cancer surveillance and catch tumors as early as possible.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to better early detection of cancers in people with Li-Fraumeni syndrome, potentially improving outcomes through earlier treatment.
What could go wrong: This is a small pilot study with only 30 participants, so results may not apply to everyone. The new MRI techniques might not reliably distinguish harmless from cancerous growths.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Li-Fraumeni syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LI-FRAUMENI SYNDROME

Contacts and locations

Locations

The Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.