New MRI scans aim to catch cancers before they grow in High-Risk families
NCT ID NCT03176836
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
Li-Fraumeni syndrome is a rare genetic condition that greatly increases the risk of developing many types of cancer. This pilot study will test three advanced MRI techniques—whole body STIR MRI, DW-MRI, and PET-MRI—in 30 people with the condition to see how well they can detect very small tumors and tell them apart from harmless growths. The goal is to improve cancer surveillance and catch tumors as early as possible.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could lead to better early detection of cancers in people with Li-Fraumeni syndrome, potentially improving outcomes through earlier treatment.
What could go wrong
This is a small pilot study with only 30 participants, so results may not apply to everyone. The new MRI techniques might not reliably distinguish harmless from cancerous growths.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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The Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada