Can Full-Body scans spot cancer early in High-Risk families?
NCT ID NCT02950987
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing whether whole body MRI scans can help find cancers early in children and adults with Li-Fraumeni syndrome, a genetic condition that greatly raises cancer risk. About 150 participants will receive annual whole body MRI scans for four years to see if they keep coming back for screening and how many cancers are detected. The goal is to see if this imaging approach is a practical and effective screening tool for this high-risk group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Whole Body MRI (imaging device)
What this could lead to
If successful, this could establish whole body MRI as a standard screening method to catch cancers early in people with Li-Fraumeni syndrome, potentially improving survival.
What could go wrong
This is an observational screening study, not a treatment trial. It may not prove that earlier detection actually improves outcomes, and false positives could cause unnecessary anxiety or procedures.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02115, United States
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Memorial Sloan-Kettering Cancer Center
New York, New York, 10065, United States