Can brain scans predict dementia risk in Late-Life depression?
NCT ID NCT07768098
First seen Aug 17, 2026 · Last updated Aug 17, 2026
Summary
This observational study follows adults aged 60 and older with late-life depression to see how the condition affects memory, dementia risk, and overall health over many years. Researchers will compare them with healthy peers of the same age and sex, using brain scans, blood tests, and memory assessments. The goal is to understand whether certain brain changes or biomarkers can predict how the illness will progress. No new treatment is being tested; the study relies on data from previous research and medical records.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this study could help identify early warning signs of dementia and other serious outcomes in older adults with late-life depression, potentially guiding earlier interventions.
- What could go wrong
- This is an observational study, so it cannot prove cause and effect. The findings may not apply to all people with late-life depression, and the long follow-up may limit the number of participants who complete all assessments.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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UZ Leuven
Leuven, Flanders, 3000, Belgium
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