Can adding estrogen to letrozole boost fertility in PCOS?

NCT ID NCT07379502

Not yet recruiting Disease control Sponsor: CMH Kharian Medical College Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will test whether adding estradiol valerate to letrozole improves the uterine lining in 60 women with PCOS compared to letrozole alone. Participants will be randomly assigned to one of two groups and monitored via ultrasound. The goal is to see if the combination leads to a thicker, healthier endometrial lining, which may help with fertility.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Letrozole and Estradiol valerate
What this could lead to: If successful, this could point toward a better way to prepare the uterine lining in women with PCOS, potentially improving fertility treatment outcomes.
What could go wrong: This is a small, early-stage study with only 60 participants. It measures endometrial changes, not pregnancy rates, so success here may not lead to higher live birth rates. Results may not apply to all women with PCOS.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

polycystic ovary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PCOS (POLYCYSTIC OVARY SYNDROME)

Contacts and locations

Locations

CMH Kharian Medical College

Khārian, Punjab Province, 50070, Pakistan

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