Can adding estrogen to letrozole boost fertility in PCOS?
NCT ID NCT07379502
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study will test whether adding estradiol valerate to letrozole improves the uterine lining in 60 women with PCOS compared to letrozole alone. Participants will be randomly assigned to one of two groups and monitored via ultrasound. The goal is to see if the combination leads to a thicker, healthier endometrial lining, which may help with fertility.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Letrozole and Estradiol valerate
What this could lead to
If successful, this could point toward a better way to prepare the uterine lining in women with PCOS, potentially improving fertility treatment outcomes.
What could go wrong
This is a small, early-stage study with only 60 participants. It measures endometrial changes, not pregnancy rates, so success here may not lead to higher live birth rates. Results may not apply to all women with PCOS.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CMH Kharian Medical College
Khārian, Punjab Province, 50070, Pakistan
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••