Could a Decades-Old smallpox vaccine stop mpox? colombia trial aims to find out
NCT ID NCT06223919
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This Phase 3 trial in Colombia tests the LC16m8 vaccine, originally developed for smallpox, to see if it can prevent mpox in people at high risk, such as men who have sex with men and those with HIV. About 8,686 participants will be randomly assigned to get the vaccine right away or after a delay. Researchers will compare infection rates and side effects between the groups over 180 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
LC16m8 (live attenuated vaccinia virus vaccine)
What this could lead to
If successful, this vaccine could help prevent mpox in high-risk populations, including people with HIV, and reduce severe illness.
What could go wrong
Mpox cases have dropped recently in Colombia, making it harder to measure effectiveness. The trial is also open-label, which can introduce bias.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Clinica Universitaria Colombia - Centro Medico Teusaquillo
Bogotá, Bogota D.C., Colombia
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Hospital Universitario San Ignacio
Bogotá, Bogota D.C., Colombia
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Infecto Clinicos
Bogotá, Bogota D.C., Colombia