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Laser light may wake up numb lips and chins after jaw surgery

NCT ID NCT07789821

Symptom relief Sponsor: National University Hospital, Singapore Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

This trial tests whether low-energy laser light applied to the skin, called photobiomodulation, can speed up recovery of sensation in the lower lip, chin, and cheek after jaw surgery. Numbness in these areas is a common side effect, affecting about one third of patients a year after surgery. Participants who develop numbness will receive either active laser treatment or an inactive sham laser, with six sessions over three weeks. Neither the participant nor the assessor will know which treatment was given, and all receive standard postoperative care. The study tracks sensory recovery over 12 months to see if the laser shortens the time to normal feeling.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Nd:YAG laser photobiomodulation (low-energy laser light applied to the skin)
What this could lead to
If it works, this could offer a non-invasive way to speed up recovery of sensation in the lip, chin, and cheek after jaw surgery, reducing long-term numbness.
What could go wrong
The trial is small (36 participants) and early, so results may not apply to everyone. The sham control helps, but the laser might not outperform it, and nerve recovery can be unpredictable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 36 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 21-80 years and above at time of orthognathic surgery. 2. Underwent bimaxillary orthognathic surgery (SSRO and Le Fort I osteotomy), without genioplasty 3. Willing and able to comply with the full 12-month follow-up schedule comprising 12 visits. Exclusion Criteria: 1. Systemic diseases known to impair peripheral nerve regeneration, including diabetes mellitus (any type), peripheral neuropathy of any aetiology, multiple sclerosis, or other demyelinating disorders. 2. Pregnant women are excluded 3. Patients with cognitive impairment are excluded 4. History of hypersensitivity or adverse reaction to laser therapy of any type. 5. Surgical complication directly attributable to the orthognathic procedure that required reoperation or microsurgical nerve repair, as these represent a fundamentally different injury severity and recovery trajectory from the neurapraxic and axonotmetic injuries targeted by this study. 6. Genioplasty performed

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Conditions

The condition(s) this trial relates to.

traumatic neuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Inferior alveolar nerve injury Infraorbital nerve injury Neurosensory disturbance following orthognathic surgery Photobiomodulation

How to take part

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  1. The official record

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