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Could hidden knee bacteria explain why ACL surgeries fail?

NCT ID NCT07009392

Knowledge-focused Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This study investigates whether silent infections or an imbalanced microbiome in the knee joint contribute to the failure of anterior cruciate ligament (ACL) reconstruction surgery. Researchers will use advanced genetic sequencing (NGS) to analyze tissue from the knee during primary or revision ACL surgery in about 100 patients. Unlike standard cultures, this technique can detect low-level or polymicrobial infections that might otherwise go unnoticed. The goal is to better understand why some ACL grafts fail and to improve future outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Next-generation sequencing (NGS) analysis of knee tissue
What this could lead to
If successful, this could reveal hidden infections or microbiome imbalances that cause ACL graft failures, potentially leading to better diagnostic and treatment strategies.
What could go wrong
This is an observational study, not a treatment trial. It may not find a clear link between the microbiome and graft failure, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient undergoing primary ACL reconstruction or revision surgery * Patient for whom access to the operative report of the primary ACL reconstruction is available * Patient affiliated with or beneficiary of a social security system * Patient who speaks French and has signed informed consent Exclusion Criteria: * Patients with preoperative signs or a history of knee joint infection * Patients suffering from diabetes, cancer, or a chronic inflammatory disease * Patients receiving immunosuppressive therapy * Patients with elevated serum inflammatory markers * Patients who have used intravenous drugs in the 3 months prior to surgery * Patients who have used antibiotics in the 3 months prior to surgery * Protected patients: adults under guardianship, curatorship, or other legal protection, persons deprived of their liberty by a judicial or administrative decision, persons under a protective measure, persons admitted to a health or social care facility for purposes other than research, and persons unable to express consent * Pregnant or breastfeeding women

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acl - anterior cruciate ligament rupture

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hôpital Privé Jean Mermoz

    RECRUITING

    Lyon, 69008, France

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