New drug aims to tame gluten reaction in celiac disease
NCT ID NCT05574010
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested an experimental drug called KAN-101 in people with celiac disease. The goal was to see if it could safely reduce the immune response to gluten. The trial included 128 participants and was split into phases to check safety and how the body processes the drug. However, the study was terminated early, so final conclusions are limited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
KAN-101
What this could lead to
If successful, KAN-101 could offer a new way to manage celiac disease by reducing the immune reaction to gluten.
What could go wrong
This trial was terminated early, so results are limited. It is still in early phases, and it is unknown if it will work for most patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Advanced Research Institute
Ogden, Utah, 84405, United States
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Agile Clinical Research Trials
Sandy Springs, Georgia, 30328, United States
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Anaheim Clinical Trials, LLC
Anaheim, California, 92801, United States
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Aventiv Research, Inc. d/b/a Centricity Research
Columbus, Ohio, 43213, United States
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Box Hill Hospital
Box Hill, Victoria, 3128, Australia
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Campbelltown Hospital
Campbelltown, New South Wales, 2560, Australia
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Celiac Disease Center at Columbia University
New York, New York, 10032, United States
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Digestive Research of Central Texas
Waco, Texas, 76712, United States
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GCP Research
St. Petersburg, Florida, 33705, United States
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Great Lakes Gastroenterology Research, LLC
Mentor, Ohio, 44060, United States
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Indiana University Health University Hospital
Indianapolis, Indiana, 46202, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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North Carolina Clinical Research
Raleigh, North Carolina, 27607, United States
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Northshore Gastroenterology Research, LLC
Westlake, Ohio, 44145, United States
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Optimal Clinical Trials
Auckland, Auckland, 1023, New Zealand
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P3 Research - Dunedin
Dunedin, Otago, 9016, New Zealand
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P3 Research - Palmerston North
Paraparaumu, Wellington Region, 5032, New Zealand
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P3 Research - Tauranga
Tauranga, Bay of Plenty, 3110, New Zealand
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P3 Research - Wellington
Wellington, Wellington Region, 6021, New Zealand
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PCRN Trials
Takapuna, Auckland, 0622, New Zealand
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Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033, United States
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Prism Research LLC dba Nucleus Network
Saint Paul, Minnesota, 55114, United States
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Quality Clinical Research
Omaha, Nebraska, 68114, United States
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Royal Adelaide Hospital
Adelaide, South Australia, 5000, Australia
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Rush University Medical Center
Chicago, Illinois, 60612, United States
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Sneeze, Wheeze & Itch Associates, LLC
Normal, Illinois, 61761, United States
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St John of God Midland Public and Private Hospitals
Midland, Western Australia, 6056, Australia
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The Royal Melbourne Hospital
Parkville, Victoria, 3050, Australia
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The University of Texas Health Science Center at Houston
Houston, Texas, 77030, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35233, United States
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University of Iowa
Iowa City, Iowa, 52242, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37212, United States
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Velocity Clinical Research, Salt Lake City
West Jordan, Utah, 84088, United States
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Waikato Hospital
Hamilton, Hamilton, 3204, New Zealand
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Wesley Research Institute
Auchenflower, Queensland, 4066, Australia