Cheaper, Needle-Free option for Post-Surgery nausea in children put to the test

NCT ID NCT04563494

Completed Symptom relief Sponsor: University of Colorado, Denver Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial tests whether giving dexamethasone as a pill works just as well as an IV injection to prevent nausea and vomiting after tonsillectomy in children aged 3 to 7. The study also looks at pain levels and drug costs. If oral dexamethasone proves non-inferior, it could offer a simpler, lower-cost alternative during IV drug shortages.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dexamethasone given by mouth or by IV
What this could lead to: If oral dexamethasone works as well as the IV form, it could offer a cheaper, easier way to prevent post-surgery nausea and vomiting in children.
What could go wrong: This is a small, single-center trial. Oral dexamethasone may not be as effective as IV, and results may not apply to all children or surgeries.

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Conditions

The condition(s) this trial relates to.

Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NAUSEA AND VOMITING, POSTOPERATIVE

Contacts and locations

Locations

Children's Hospital of Colorado

Aurora, Colorado, 80045, United States

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