New shot could shrink nasal polyps and ease stuffy nose

NCT ID NCT06834360

Ongoing Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests itepekimab, an injectable drug, in 216 adults with chronic sinusitis and nasal polyps that are not well-controlled by standard nasal sprays. Participants receive itepekimab or a placebo for 52 weeks, plus a nasal spray. The study measures changes in polyp size and nasal congestion. It aims to see if itepekimab can improve symptoms and reduce the need for surgery or steroids.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

itepekimab

What this could lead to

If it works, this could provide a new treatment option to shrink nasal polyps and ease congestion for people whose symptoms are not controlled by standard sprays.

What could go wrong

This is a Phase 3 trial, but results are not yet known. The drug may not work better than placebo, and side effects are possible. It is an add-on therapy, not a standalone cure.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC RHINOSINUSITIS WITH NASAL POLYPS

Contacts and locations

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Locations

Advanced ENT & Allergy - Louisville- Site Number : 8400007

Louisville, Kentucky, 40220, United States
Advanced Research Institute - New Port Richey- Site Number : 8400014

New Port Richey, Florida, 34653, United States
Allergy, Asthma and Clinical Research- Site Number : 8400002

Oklahoma City, Oklahoma, 73120, United States
Cedars-Sinai Medical Center- Site Number : 8400030

Los Angeles, California, 90048, United States
Centro de Pesquisa Clínica de Marília - CPCLIM- Site Number : 0760002

Marília, São Paulo, 17504-072, Brazil
Clinica de Alergia Martti Antila- Site Number : 0760003

Sorocaba, São Paulo, 18040-425, Brazil
Ear and Sinus Institute- Site Number : 8400048

Fort Worth, Texas, 76104, United States
Excel ENT of Alabama- Site Number : 8400052

Birmingham, Alabama, 35244, United States
Fundação Faculdade Regional de Medicina de São José do Rio Preto- Site Number : 0760005

São José do Rio Preto, São Paulo, 15090-000, Brazil
Investigational Site Number : 0320001

Buenos Aires, 1414, Argentina
Investigational Site Number : 0320002

Buenos Aires, 1121, Argentina
Investigational Site Number : 0320003

Mendoza, 5500, Argentina
Investigational Site Number : 0320004

Corrientes, 3400, Argentina
Investigational Site Number : 0320005

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Investigational Site Number : 0360001

Spearwood, Western Australia, 6163, Australia
Investigational Site Number : 0360002

Brisbane, Queensland, 4029, Australia
Investigational Site Number : 0360003

Bella Vista, New South Wales, 2153, Australia
Investigational Site Number : 0560001

Leuven, 3000, Belgium
Investigational Site Number : 0560002

Ghent, 9000, Belgium
Investigational Site Number : 0560004

Gesves, Namur, 5340, Belgium
Investigational Site Number : 0560006

Alken, 3570, Belgium
Investigational Site Number : 1240003

Québec, Quebec, G1V 4W2, Canada
Investigational Site Number : 1240012

Québec, Quebec, G2J 0C4, Canada
Investigational Site Number : 1240014

Ottawa, Ontario, K1G 6C6, Canada
Investigational Site Number : 1240015

Cambridge, Ontario, N1R 8L4, Canada
Investigational Site Number : 1240017

Vancouver, British Columbia, V6A 2W1, Canada
Investigational Site Number : 1240019

Burlington, Ontario, L7R 3P9, Canada
Investigational Site Number : 1520001

Concepción, Biobio, 4070094, Chile
Investigational Site Number : 1520002

Quillota, Valparaiso, 2260877, Chile
Investigational Site Number : 1520003

Santiago, Reg Metropolitana de Santiago, 7500505, Chile
Investigational Site Number : 1520004

Talcahuano, Biobio, 2687000, Chile
Investigational Site Number : 1560001

Beijing, 100730, China
Investigational Site Number : 1560002

Jinan, 250022, China
Investigational Site Number : 1560003

Yantai, 264001, China
Investigational Site Number : 1560004

Chengdu, 610017, China
Investigational Site Number : 1560006

Shenyang, 110004, China
Investigational Site Number : 1560009

Zibo, 255036, China
Investigational Site Number : 1560012

Jingzhou, 434020, China
Investigational Site Number : 1560014

Wuhan, 430060, China
Investigational Site Number : 1560017

Taiyuan, 030001, China
Investigational Site Number : 1560019

Hangzhou, 310003, China
Investigational Site Number : 1560020

Baotou, 014040, China
Investigational Site Number : 1560021

Nanning, 530021, China
Investigational Site Number : 1560023

Taiyuan, 030001, China
Investigational Site Number : 1560024

Suzhou, 215006, China
Investigational Site Number : 1560025

Chongqing, 400016, China
Investigational Site Number : 2030001

Prague, 150 06, Czechia
Investigational Site Number : 2030002

Hradec Králové, 500 05, Czechia
Investigational Site Number : 2030003

Pardubice, 532 03, Czechia
Investigational Site Number : 2030004

Prague, 100 34, Czechia
Investigational Site Number : 2030005

Pilsen, 305 99, Czechia
Investigational Site Number : 2080001

Aarhus, 8200, Denmark
Investigational Site Number : 2080002

Køge, 4600, Denmark
Investigational Site Number : 2080004

Copenhagen, 2100, Denmark
Investigational Site Number : 2500001

Nantes, 44093, France
Investigational Site Number : 2500004

Marseille, 13005, France
Investigational Site Number : 2500005

Toyama, 939-2716, Japan
Investigational Site Number : 2500007

Toulouse, 31059, France
Investigational Site Number : 2500010

Poitiers, 86021, France
Investigational Site Number : 2500011

Bordeaux, 33076, France
Investigational Site Number : 2500014

Pontoise, 95300, France
Investigational Site Number : 2760001

Dresden, 01307, Germany
Investigational Site Number : 2760002

Leipzig, 04103, Germany
Investigational Site Number : 2760005

Hamburg, 20246, Germany
Investigational Site Number : 2760006

Dresden, 01139, Germany
Investigational Site Number : 2760007

Mainz, 55131, Germany
Investigational Site Number : 2760008

Villingen-Schwenningen, 78052, Germany
Investigational Site Number : 3480001

Szeged, 6720, Hungary
Investigational Site Number : 3480005

Budapest, 1026, Hungary
Investigational Site Number : 3760001

Nahariya, 2210001, Israel
Investigational Site Number : 3760002

Rehovot, 7610001, Israel
Investigational Site Number : 3760003

Haifa, 3104802, Israel
Investigational Site Number : 3760004

Jerusalem, 9112001, Israel
Investigational Site Number : 3800001

Milan, Milano, 20132, Italy
Investigational Site Number : 3800003

Catania, 95123, Italy
Investigational Site Number : 3800005

Naples, Napoli, 80131, Italy
Investigational Site Number : 4840001

Guadalajara, Jalisco, 44100, Mexico
Investigational Site Number : 4840002

Veracruz, 91900, Mexico
Investigational Site Number : 4840007

Chihuahua City, 31217, Mexico
Investigational Site Number : 4840008

Monterrey, Nuevo León, 64718, Mexico
Investigational Site Number : 5280001

Utrecht, 3584 CX, Netherlands
Investigational Site Number : 5280002

Amsterdam, 1081 HV, Netherlands
Investigational Site Number : 6160001

Bielsko-Biala, Silesian Voivodeship, 43-300, Poland
Investigational Site Number : 6160002

Lodz, Lódzkie, 90-302, Poland
Investigational Site Number : 6160004

Poznan, Greater Poland Voivodeship, 60-693, Poland
Investigational Site Number : 6160005

Wroclaw, Lower Silesian Voivodeship, 50-750, Poland
Investigational Site Number : 6420001

Bucharest, 022328, Romania
Investigational Site Number : 6420002

Brasov, 500283, Romania
Investigational Site Number : 6420003

Brasov, 500091, Romania
Investigational Site Number : 7240002

Santander, Cantabria, 39008, Spain
Investigational Site Number : 7240004

L'Hospitalet de Llobregat, Catalunya [Cataluña], 08907, Spain
Investigational Site Number : 7240006

Barcelona, Barcelona [Barcelona], 08003, Spain
Investigational Site Number : 7240008

Pamplona, Navarre, 31008, Spain
Investigational Site Number : 7240010

Madrid, 28034, Spain
Investigational Site Number : 7240012

Madrid, 28040, Spain
Investigational Site Number : 7920001

Bursa, 16059, Turkey (Türkiye)
Investigational Site Number : 7920002

Istanbul, 34360, Turkey (Türkiye)
Investigational Site Number : 7920003

Ankara, 06230, Turkey (Türkiye)
Investigational Site Number : 8260001

London, London, City of, W2 1NY, United Kingdom
Investigational Site Number : 8260002

Wigan, Lancashire, Wn6 9ep, United Kingdom
Investigational Site Number : 8260003

Taunton, Somerset, TA1 5DA, United Kingdom
Johns Hopkins Hospital- Site Number : 8400017

Baltimore, Maryland, 21287, United States
One Of A Kind Clinical Research Center- Site Number : 8400034

Napa, California, 94558, United States
Private Practice - Dr. Nelson Rosário- Site Number : 0760001

Curitiba, Paraná, 80810-100, Brazil
Spartanburg-Greer ENT & Allergy- Site Number : 8400039

Greer, South Carolina, 29650, United States
Thomas Jefferson University Hospital- Site Number : 8400044

Philadelphia, Pennsylvania, 19107, United States
University of Cincinnati Medical Center- Site Number : 8400022

Cincinnati, Ohio, 45219, United States
University of Florida - Jacksonville- Site Number : 8400053

Jacksonville, Florida, 32209, United States
University of Illinois at Chicago- Site Number : 8400003

Chicago, Illinois, 60607, United States
Velocity Clinical Research - Lafayette- Site Number : 8400026

Lafayette, Louisiana, 70508, United States
Velocity Clinical Research - San Diego- Site Number : 8400041

La Mesa, California, 91942, United States