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Could insulin resistance be a hidden driver of heart disease in naples?

NCT ID NCT07785518

Knowledge-focused Sponsor: Comune di Napoli Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time

Summary

This large observational study looks at health records from general practitioners in Naples to estimate how common insulin resistance is in the local population. It also examines whether people with insulin resistance have a higher rate of cardiovascular disease compared to those without it. The study uses a simple blood-based marker called TyG to identify insulin resistance. By analyzing data from over 120,000 people, the researchers hope to uncover patterns that could inform future prevention strategies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this study finds a strong link between insulin resistance and heart disease, it could help identify people at higher risk and guide prevention efforts in the community.
What could go wrong
This is an observational study, so it can show associations but not prove cause and effect. The results may not apply to other populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

123,752 people

The number who actually took part.

Started

Jan 2026

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All the subjects registered in the database of COMEGEN aged between 18 and 60 without a diagnosis of diabetes

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * all the subjects who have a registered value of glucose and triglycerides in the same day within the last 6 months Exclusion Criteria: * diagnosis of overt diabetes

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome cardiovascular disorder hyperinsulinism Insulin Resistance metabolic syndrome X

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardio vascular disease Insulin resistance syndrome Prevalence

Contacts and locations

Locations

  • Comune di Napoli

    Naples, 80100, Italy

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