Brain tumor drug penetration study halted early

NCT ID NCT04424966

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 26 times

Summary

This early-phase trial aimed to see how well the drug infigratinib reaches brain tumors in patients with recurrent high-grade glioma (a type of brain cancer) who were scheduled for surgery. Only 7 of the planned 20 participants were enrolled before the study was terminated. The main goal was to measure drug levels in tumor tissue, blood, and spinal fluid after a single dose.

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Contacts and locations

Locations

  • Chandler Regional Medical Center

    Chandler, Arizona, 85224, United States

  • HonorHealth Scottsdale Osborn Medical Center

    Scottsdale, Arizona, 85251, United States

  • St. Joseph's Hospital and Medical Center

    Phoenix, Arizona, 85013, United States

Conditions

Explore the condition pages connected to this study.