Lab-Grown vessels could revolutionize dialysis access

NCT ID NCT02644941

NEW Completed Disease control Sponsor: Humacyte, Inc. Source: ClinicalTrials.gov ↗

First seen Aug 19, 2026 · Last updated Aug 19, 2026

Summary

This trial is testing whether a lab-grown human blood vessel (called a Human Acellular Vessel) can serve as a better connection point for hemodialysis than the standard synthetic grafts. People with end-stage kidney disease who need dialysis often require a reliable access point in their arm. The study compares how long the lab-grown vessel stays usable without needing repairs or replacement, compared to the synthetic ePTFE graft. If the lab-grown vessel proves more durable, it could mean fewer complications and surgeries for people on dialysis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Human Acellular Vessel (HAV), a lab-grown biological tube made from human cells, compared to standard synthetic ePTFE grafts.
What this could lead to: If successful, this could provide a more durable and infection-resistant option for dialysis access, reducing the need for repeat surgeries.
What could go wrong: The trial is still in phase 3, and results may not show a clear benefit. There are risks of clotting, infection, or the vessel failing over time.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease end stage renal failure kidney failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

END STAGE RENAL DISEASE HEMODIALYSIS RENAL FAILURE VASCULAR ACCESS

Contacts and locations

Locations

Arizona Kidney Disease and Hypertension Center (AKDHC)

Phoenix, Arizona, 85012, United States
Balboa Nephrology

San Diego, California, 92123, United States
Baylor Scott and White Research Institute

Dallas, Texas, 75226, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Carondelet St. Mary's Hospital

Tucson, Arizona, 85745, United States
Duke University Hospital

Durham, North Carolina, 27705, United States
General Surgery and Vascular Access

Fresno, California, 93720, United States
Greenwood Leflore Hospital

Greenwood, Mississippi, 38930, United States
Grupo de Estudos Vasculares

Porto, 4050-190, Portugal
Guy´s Hospital, Kings´College London

London, Greater London, SE1 9RT, United Kingdom
Hillel Jaffe Medical Center

Hadera, 38100, Israel
Kaiser Permanente

Portland, Oregon, 97201, United States
Ladenheim Dialysis Access Center

Fresno, California, 93710, United States
Leeds General Infirmary

Leeds, LS1 3EX, United Kingdom
Leicester General Hospital

Leicester, East Midlands/ Leicestershire, LE5 4PW, United Kingdom
Medical University of South Carolina (MUSC)

Orangeburg, South Carolina, 29118, United States
Michigan Cardiovascular Institute

Flint, Michigan, 48507, United States
Queen Elizabeth Hospital Birmingham

Birmingham, West Midlands, B15 2TH, United Kingdom
Queen Elizabeth University Hospital Glasgow

Glasgow, G51 4TF, United Kingdom
Rambam Health Care Campus

Haifa, Haifa District, 3109601, Israel
Rutgers-New Jersey Medical School

Newark, New Jersey, 07103, United States
Samodzielny Publiczyn Centralny Szpital Klinziczny w Warszawie - Uniwersyteckie Centrum Kliniczne Warszawskiego Uniwersytetu Medycznego

Warsaw, 02-097, Poland
Sharee Zedek Medical Center

Jerusalem, 9103102, Israel
Southwest Vascular Access Center

Alsip, Illinois, 60803, United States
Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego im. Karola Marcinkowskiego

Poznan, 61-848, Poland
The Cardiovascular Care Group

Westfield, New Jersey, 07090, United States
The Chaim Sheba Medical Center

Ramat Gan, Tel Aviv, 52621, Israel
University of California Irvine (UCI) Medical Center

Irvine, California, 92868, United States
University of Maryland Medical Center

Baltimore, Maryland, 21201, United States
University of South Florida

Tampa, Florida, 33606, United States
University of Wisconsin

Madison, Wisconsin, 53706, United States
Universitätsklinikmn Erlangen, Gefäßchirurgie - Chirurgisches Zentrum

Erlangen, Bavaria, 91054, Germany
Universitätsklinikum Frankfurt Klinik für Gefäß- und Endovascular-Chirurgie

Frankfurt am Main, Hesse, 60590, Germany
VA Long Beach Healthcare System

Long Beach, California, 90822, United States
VA Sacramento Medical Center

Mather, California, 95655, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Wojewódzki Szpital Specjalistyczny we Wrocławiu

Wroclaw, 51-124, Poland
Yitzhak Shamir Medical Center - Assaf Harofeh

Tzrifin, 70300, Israel

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