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Blood test may spare throat cancer patients from full radiation

NCT ID NCT06915038

Recruiting now Disease control Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This trial is testing whether a blood test that detects HPV DNA can help doctors safely reduce the amount of radiation given after surgery for HPV-positive throat cancer. After surgery, patients with undetectable HPV DNA in their blood may receive a lower dose of radiation, while those with detectable levels receive standard or higher doses. The goal is to see if this personalized approach can maintain cancer control while minimizing treatment side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
NavDx blood test and reduced-dose adjuvant radiation (30 or 40 Gray)
What this could lead to
If successful, this approach could allow many throat cancer patients to receive less radiation after surgery, reducing side effects while maintaining high cure rates.
What could go wrong
The trial is relatively small and early, and it's possible that reducing radiation based on blood test results could lead to higher recurrence rates in some patients. The test's accuracy and long-term outcomes are still being evaluated.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

oropharynx squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck tonsil cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HPV POSITIVE CANCER SQUAMOUS CELL CARCINOMA OF OROPHARYNX THROAT CANCER TONSIL CANCER

Contacts and locations

Locations

  • IU Health Joe and Shelly Schwarz Cancer Center

    RECRUITING

    Carmel, Indiana, 46032, United States

  • Indiana University Melvin and Bren Simon Comprehensive Cancer Center

    RECRUITING

    Indianapolis, Indiana, 46202, United States

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