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Can a nap cement what we learn? brain study investigates

NCT ID NCT05910762

Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This study investigates how the brain learns to recognize patterns across experiences and how sleep helps solidify those memories. Healthy adults aged 18-35 will perform learning tasks while their brain activity is monitored using MRI and EEG. The researchers will also use sound cues during sleep to see if they can influence memory consolidation. The goal is to understand the fundamental mechanisms of learning and memory, which could inform future educational and therapeutic approaches.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Behavioral tasks (associative inference and category learning) combined with sleep and brain imaging (fMRI and EEG)
What this could lead to
If successful, this could clarify how the brain forms and consolidates structured knowledge, potentially informing educational strategies and treatments for memory disorders.
What could go wrong
This is an early-stage observational study, so results may not directly translate to real-world applications. The findings depend on complex brain imaging and sleep monitoring, which may have variability.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

119 people

The number who actually took part.

Started

Jun 2023

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Between 18 and 35 years of age (all aims) * Not a member of a vulnerable population (all aims) * Normal or corrected-to-normal vision (all aims) * Normal hearing (all aims) * Able to speak English fluently (all aims) * No prior history of major psychiatric or neurological disorders (Aims 1 and 2; MRI-specific) * Not currently taking any antidepressants or sedatives (Aims 1 and 2; MRI-specific) * No known neurological disorders (Aim 3; EEG-specific) Exclusion Criteria: * The investigators will exclude individuals with MR contraindications such as non-removable biomedical devices or metal in or on the body (Aims 1 and 2; MRI-specific) * Claustrophobia (Aims 1 and 2; MRI-specific) * Pregnant women will also be excluded from neuroimaging, as the effects of MR on pregnancy are not fully understood (Aims 1 and 2; MRI-specific)

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Conditions

The condition(s) this trial relates to.

disease human disease learning disability sleep disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Consolidation HUMANS Learning Sleep

Contacts and locations

Locations

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.