Sound waves zapping liver tumors? new device tested in 24 patients

NCT ID NCT04573881

Ongoing Disease control Sponsor: HistoSonics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests a device called HistoSonics that uses focused ultrasound (sound waves) to mechanically destroy liver tumors without heat or needles. It includes 24 adults with liver cancer or tumors that spread to the liver. The main goals are to see if the device can fully cover the tumor and to check for serious side effects within 30 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Histotripsy (focused ultrasound device)
What this could lead to: If successful, this could offer a non-invasive, needle-free option to destroy liver tumors without surgery or radiation.
What could go wrong: This is a very early, small study (24 people) with no control group. It only checks if the device can cover the tumor and if major complications occur within 30 days. Long-term benefits or risks are unknown.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma liver and intrahepatic bile duct neoplasm Liver Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATOCELLULAR CARCINOMA LIVER METASTASES LIVER NEOPLASMS

Contacts and locations

Locations

Istituto Clinico Humanitas - Humanitas Mirasole S.P.A.

Milan, Italy
Leeds Teaching Hospitals NHS Trust

Leeds, LS9 7TF, United Kingdom
Städtisches Klinikum Braunschweig gGmbH

Braunschweig, Germany
The Newcastle Upon Tyne Hospitals NHS Foundation Trust

Newcastle, NE7 7DN, United Kingdom
Universitätsklinikum Magdeburg Klinik für Radiologie und Nuklearmedizin

Magdeburg, 39120, Germany
Vall d'Hebron

Barcelona, Spain

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