Sound waves zapping liver tumors: no knife needed?

NCT ID NCT04572633

Ongoing Disease control Sponsor: HistoSonics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests a device called HistoSonics that uses focused ultrasound waves to mechanically destroy liver tumors without heat, needles, or incisions. About 47 adults with liver cancer or tumors that spread to the liver will receive this treatment. The main goals are to see if the device can fully cover the tumor and to check for serious side effects within 30 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Histotripsy (focused ultrasound device)
What this could lead to: If successful, this could offer a non-invasive, needle-free option to destroy liver tumors, potentially reducing the need for surgery or radiation.
What could go wrong: This is an early-stage, single-arm trial with only 47 participants, so results may not apply to everyone. Risks include incomplete tumor destruction and procedure-related complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma liver and intrahepatic bile duct neoplasm Liver Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATOCELLULAR CARCINOMA LIVER METASTASES LIVER NEOPLASMS

Contacts and locations

Locations

Medical College of Wisconsin/Froedtert Hospital

Milwaukee, Wisconsin, 53226, United States
Miami Cancer Institute

Miami, Florida, 33176, United States
Tampa General Hospital

Tampa, Florida, 33606, United States
University Hospital - UW Health

Madison, Wisconsin, 53792-3252, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Michigan Hospital

Ann Arbor, Michigan, 48109-5030, United States

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