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Scientists hunt for clues to predict T-DXd success in metastatic cancer

NCT ID NCT04257162

Ongoing Knowledge-focused Sponsor: SOLTI Breast Cancer Research Group Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study collects tumor and blood samples from 180 people with metastatic cancer who are receiving or have received the drug T-DXd. Researchers will analyze these samples to find genetic markers that predict whether the drug will work well. The goal is to improve treatment decisions for future patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors predict which patients will benefit most from T-DXd, leading to more personalized treatment for metastatic cancer.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly test a new therapy. Results may not change practice immediately and depend on sample quality and analysis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metastatic malignant neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC CANCER

Contacts and locations

Locations

  • H.Univ. Arnau de Vilanova de Lleida

    Lleida, Lleida, Spain

  • Hospital Clínic de Barcelona

    Barcelona, Barcelona, 08036, Spain

  • Hospital La Paz

    Madrid, Madrid, 28046, Spain

  • Hospital Universitari Vall d' Hebron

    Barcelona, Spain

  • Hospital Universitario 12 de octubre

    Madrid, Spain

  • Hospital Universitario Virgen de la Arrixaca

    Murcia, 30120, Spain

  • Hospital Universitario Virgen del Rocio

    Seville, Spain

  • Hospital Universitario de Canarias

    Santa Cruz de Tenerife, Canary Islands, 38320, Spain

  • Hospital Universitario de Jerez

    Jerez de la Frontera, Cadiz, 11407, Spain

  • Hospital Virgen de Macarena

    Seville, Sevilla, Spain

  • Hospital Virgen de la Victoria

    Málaga, Spain

  • Hospital del Mar

    Barcelona, Barcelona, 08003, Spain

  • ICO Badalona

    Badalona, Barcelona, Spain

  • ICO Hospitalet

    Barcelona, Spain

  • Instituto Valenciano de Oncología (IVO)

    Valencia, Valencia, 46009, Spain

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