Cure My Disease

Don't miss your cure!

 Log in / Sign up

Grape compounds may retrain the body's fuel switch, a trial puts it to the test

NCT ID NCT07800988

Knowledge-focused Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This study tests whether polyphenols from whole grapes can improve metabolic flexibility, the body's ability to shift between burning carbohydrates and fat after a meal. Researchers will give 20 adults, half lean and half with overweight or obesity, a single dose of grape powder or a placebo before a high-fat meal. They will measure how the body's fuel use changes and how well mitochondria, the energy centers of cells, respond. The goal is to see if whole grapes, not just purified extracts, can boost fat oxidation in people with different body types.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Freeze-dried whole grape powder
What this could lead to
If grape polyphenols improve the body's ability to switch between burning carbs and fat, this could point toward a dietary strategy to support metabolic health in people with obesity.
What could go wrong
This is a small, early-stage study with only 20 participants, so results may not apply broadly. The effect is measured after a single dose, and any benefit might not persist with regular consumption.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women aged 25-60 years * BMI 18-24.9 kg/m² (lean phenotype, n=10) or BMI 25-40 kg/m² (overweight/obesity phenotype, n=10) * Low habitual grape consumption * Weight stable (no change \>5% in prior 6 months) and not actively attempting weight change * White blood cell count within normal limits Exclusion Criteria: * Current smoking; drug or alcohol abuse * Claustrophobia or psychiatric conditions that would make a 40-hour confined stay especially distressing or harmful * Weight instability, recent/active weight-loss attempts, or structured exercise initiation during the study * Hormone replacement therapy or medications known to affect metabolism * Pregnant or breastfeeding * Current or prior bulimia nervosa, binge eating disorder, or anorexia nervosa * Grape allergy, or food allergies/intolerances precluding use of the metabolic kitchen * Any condition that, in the PI's opinion, would make participation unsafe or could interfere with conduct/interpretation of the study

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Healthy adult are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy adult Obesity & overweight

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.