New DNA test may spot kidney rejection without a needle

NCT ID NCT07060716

Recruiting now Diagnosis Sponsor: Insight Molecular Diagnostics Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a donor-derived cell-free DNA (dd-cfDNA) test can accurately detect rejection in kidney transplant recipients. Researchers will compare the test results to standard biopsy findings in 125 adults who are at least 12 days post-transplant. If the test works well, it could offer a less invasive way to monitor transplant health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: donor-derived cell-free DNA test
What this could lead to: If successful, this test could offer a simpler, less invasive way to monitor kidney transplant health and catch rejection early.
What could go wrong: This is an observational study, not a treatment trial. The test may not be accurate enough to replace biopsies, and results may vary across patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CELL FREE DNA KIDNEY TRANSPLANT REJECTION

Contacts and locations

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Locations

Baylor, Scott & White Research Institute
RECRUITING

Dallas, Texas, 75246, United States
Charite Universitatsmedizin
ACTIVE_NOT_RECRUITING

Berlin, 10117, Germany
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Institute of Immunology - Transplantation Immunology
ACTIVE_NOT_RECRUITING

Heidelberg, Baden-Wurttemberg, 69120, Germany
Intermountain Health
RECRUITING

Murray, Utah, 84107, United States
Mayo Clinic in Florida
RECRUITING

Jacksonville, Florida, 32224, United States
Tampa General Hospital
RECRUITING

Tampa, Florida, 33606, United States

Contact Email: •••••@•••••
University of Pittsburgh Medical Center
ACTIVE_NOT_RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Southern California Keck School of Medicine
ACTIVE_NOT_RECRUITING

Los Angeles, California, 90033, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States

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