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Evaluation of the efficacy of topical application of liquid nitrogen and ascorbic acid in treatment of gingival pigmentation

NCT ID NCT07810101

NEW Sponsor: Al-Azhar University Source: ClinicalTrials.gov ↗

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Recruiting now
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Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
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Paused for now. It may or may not start again.
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Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. The treatment could once be requested outside a study, but no longer can.
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First seen Sep 09, 2026 · Last updated Sep 09, 2026

Summary

Aim of study The present study will be designed to evaluate the clinical and histomorphometric outcomes of using topical liquid nitrogen and topical ascorbic acid in gingival depigmentation. Primary outcome: • Clinical severity and extension of gingival pigmentation. Secondary outcome: • Histologic assessment of the melanin forming cells.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals with mild-to-severe anterior melanin gingival pigmentation in the anterior portion of the upper and lower gingiva according to Dummet's classification will be involved. * The patients included in this study will be Type 1 individuals according to American Society of Anesthesiology . * The age of the patients ranges between 18 and 40 years. Exclusion Criteria: * smoker patients * pregnant and lactating women * patients with any systemic disease that may induce the production of melanin * patients with periodontal disease, non vital anterior teeth * patients with known hypersensitivity to ascorbic acid * patients who had previous depigmentation procedures.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingiival hyperpigmentation Gingival pigmentation

How to take part

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  1. The places running it

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Contacts and locations

Locations

  • Faculty of dental medicine, Alazhar university, Assiut branch

    Asyut, Asyut Governorate, 71511, Egypt

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