Gene therapy tackles Alzheimer's in High-Risk patients

NCT ID NCT03634007

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 33 times

Summary

This study tested a gene therapy called LX1001 in 15 people with a specific genetic form of Alzheimer's disease (APOE4 homozygotes). The goal was to check if the treatment is safe and to look for side effects. Participants had mild cognitive impairment or mild to moderate dementia due to Alzheimer's.

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Contacts and locations

Locations

  • Duke University

    Durham, North Carolina, 27708, United States

  • K2 Medical Research

    Maitland, Florida, 32751, United States

  • PPD- Orlando Research Unit

    Orlando, Florida, 32806, United States

  • Weill Cornell Medicine

    New York, New York, 10021, United States

Conditions

Explore the condition pages connected to this study.