New drug cocktail aims to fight Hard-to-Treat liver cancers

NCT ID NCT05775159

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing several new immunotherapy drugs, alone or combined with standard chemotherapy, in people with advanced liver or bile duct cancer. The goal is to see if these combinations can shrink tumors or slow the disease. About 294 adults whose cancer has spread or cannot be removed by surgery will participate.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Volrustomig, Rilvegostomig, Bevacizumab, Lenvatinib, Gemcitabine, Cisplatin

What this could lead to

If successful, this trial could point toward more effective treatment options for advanced liver and bile duct cancers, potentially improving tumor shrinkage and delaying disease progression.

What could go wrong

This is an early phase 2 trial with a small number of participants, so results may not apply to all patients. The drug combinations may cause significant side effects, and there is no guarantee of benefit.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

biliary tract cancer Biliary Tract Neoplasms hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BILIARY TRACT CANCER HEPATOCELLULAR CARCINOMA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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Birmingham, Alabama, 35233, United States
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Costa Mesa, California, 92627, United States
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Los Angeles, California, 90089, United States
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Orange, California, 92868, United States
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Miami Beach, Florida, 33140, United States
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Dyer, Indiana, 46311, United States
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Kansas City, Kansas, 66103, United States
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New York, New York, 10065, United States
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Dallas, Texas, 75251, United States
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Fairfax, Virginia, 22031, United States
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Beijing, 100050, China
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Beijing, 100142, China
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Beijing, 101100, China
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Chengdu, 610000, China
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Chengdu, 610041, China
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Chongqing, 400030, China
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Fuzhou, 350007, China
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Guangzhou, 510060, China
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Guangzhou, 510515, China
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Harbin, 150081, China
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Hefei, 230001, China
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Hefei, 230022, China
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Hefei, 230601, China
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Nanchang, 330006, China
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Nanning, 530021, China
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Shandong, China
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Shanghai, 200032, China
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Xi'an, 710038, China
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Zhengzhou, 450008, China
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Hong Kong, 999077, Hong Kong
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Shatin, 00000, Hong Kong
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Florence, 50134, Italy
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Milan, 20132, Italy
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Naples, 80131, Italy
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Rozzano, 20089, Italy
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Chūōku, 104-0045, Japan
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Kashiwa, 277-8577, Japan
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Yokohama, 241-8515, Japan
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Seongnam-si, 463-712, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Barcelona, 08036, Spain
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Barcelona, 8035, Spain
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Madrid, 28007, Spain
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Madrid, 28040, Spain
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Pamplona, 31008, Spain
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Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 833, Taiwan
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Liuying, 736, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 11259, Taiwan
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Taoyuan, 333, Taiwan
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Cambridge, CB2 0QQ, United Kingdom
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Edinburgh, EH4 2XU, United Kingdom
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London, NW3 2QG, United Kingdom
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Manchester, M20 4BX, United Kingdom