Experimental cell therapy for tough leukemia shows early promise but trial halted

NCT ID NCT05886491

First seen Oct 31, 2025 · Last updated May 14, 2026 · Updated 31 times

Summary

This study tested a new cell therapy called GDX012 in 16 people with acute myeloid leukemia (AML) that returned or didn't respond to treatment. The main goals were to check safety and find the best dose. The trial was stopped early, so results are limited, but the approach aims to control the disease rather than cure it.

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Contacts and locations

Locations

  • City of Hope

    Duarte, California, 91010, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Comprehensive Cancer Center of Northwestern University

    Chicago, Illinois, 60611, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • National Cancer Center Hospital East

    Kashiwa, 277-8577, Japan

  • Sarah Cannon/CBCI

    Denver, Colorado, 80218, United States

  • Thomas Jefferson University

    New York, New York, 10065, United States

  • Tri-Star BMT/Sarah Cannon Nashville

    Nashville, Tennessee, 37203, United States

  • University of Alabama at Birmingham (UAB) Hospital

    Birmingham, Alabama, 35205, United States

  • Washington University

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.