Can a gentler spinal anesthesia keep frail patients' blood pressure steadier during hip surgery?
NCT ID NCT06583213
First seen Aug 27, 2026 · Last updated Sep 01, 2026 · Updated 3 times
Summary
This trial tests whether giving spinal anesthesia in small, divided doses through a tiny tube keeps blood pressure more stable than a single standard dose in frail patients over 60 with hip fractures. Researchers will monitor blood pressure during the two-hour surgery and track pain scores for a day afterward. The goal is to find an anesthesia approach that reduces the risk of dangerous blood pressure swings in this vulnerable group.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Fractional spinal anesthesia with a low-dose bupivacaine and dexmedetomidine mixture delivered through an intrathecal catheter
- What this could lead to
- If it works, this could point toward a safer way to give spinal anesthesia to frail older adults, reducing dangerous blood pressure drops during hip fracture surgery.
- What could go wrong
- This is a small, early-stage comparison in 44 patients, so the results may not apply broadly. The procedure itself carries risks like infection or nerve injury, and the low-dose approach might not always provide enough anesthesia.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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44 people
The number who actually took part.
- Started
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Sep 2024
- Finished
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May 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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60 to 100 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients with hip fractures. * Patients age \>60 years old. * ASA ≤ 3. Patients with a CFS score ≥5 Exclusion Criteria: * Patients on anticoagulant medication. * Planned for general anaesthesia . * Patients had atrial fibrillation.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ain Shams University
Cairo, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Effect of intrathecal dexmedetomidine as an adjuvant to hyperbaric bupivacaine on the incidence of postoperative delirium in elderly patients undergoing hip fracture surgeries under spinal anesthesia
- Can a new hip buffer restore mobility after fractures?
- Can diet and exercise rebuild strength after a hip fracture?
- Can a Bone-Strengthening infusion given right after hip surgery prevent a second break?
- Home rehab after hip fracture: a new hope for independence?
- Could a simple education program be the key to better hip fracture recovery?