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Eye drops put to the test for Post-Cataract surgery swelling

NCT ID NCT06164743

Symptom relief Sponsor: VivaVision Biotech, Inc Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 11, 2026 · Last updated Sep 11, 2026

Summary

Researchers are testing an experimental eye drop called VVN461 to see if it can reduce inflammation after routine cataract surgery. The trial enrolls adults who are scheduled for cataract removal and lens replacement in one eye. Participants receive either VVN461 at one of two strengths or a vehicle drop, and researchers measure the level of inflammatory cells in the eye and track any side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
VVN461 ophthalmic solution, an experimental eye drop
What this could lead to
If it works, VVN461 could offer an alternative eye drop for controlling inflammation after cataract surgery.
What could go wrong
This is a mid-stage trial with about 91 participants, so results may not hold in larger groups. Eye drops can cause stinging, redness, or other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

91 people

The number who actually took part.

Started

Jan 2024

Finished

May 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ≥21 years of age and in good general health at Visit 1 (Screening) * Willing and able to provide informed consent and provide relevant privacy authorization(s) * Willing and able to comply with study requirements and visit schedule * Clear ocular media (other than cataract) in the study eye * Planning to undergo routine unilateral cataract surgery via phacoemulsification extraction and implantation of an intraocular lens. Exclusion Criteria: * Any ocular pain at Visit 1 (Screening) * Recent use of corticosteroids or oral non-steroidal anti-inflammatory drugs

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Conditions

The condition(s) this trial relates to.

Inflammation inflammatory disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Inflammation

Contacts and locations

Locations

  • Center For Sight - Las Vegas

    Las Vegas, Nevada, 89145, United States

  • Cincinnati Eye Institute

    Cincinnati, Ohio, 45242, United States

  • Comprehensive Eye Care, Ltd

    Washington, Missouri, 63090, United States

  • Houston Eye Associates

    Houston, Texas, 77708, United States

  • ICON Eye Care

    Grand Junction, Colorado, 81501, United States

  • Keystone Research

    Austin, Texas, 78731, United States

  • Levenson Eye Associates

    Jacksonville, Florida, 32204, United States

  • Martel Eye Associates

    Rancho Cordova, California, 95670, United States

  • North Bay Eye Associates

    Petaluma, California, 94954, United States

  • United Medical Research Institute

    Inglewood, California, 90301, United States

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