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Leg cuffs plus walking: a new way to steady Parkinson's balance?

NCT ID NCT07831980

NEW Symptom relief Sponsor: National Cheng-Kung University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

People with Parkinson's disease often struggle with balance and anxiety, and the two can make each other worse, especially when they try to walk and think at the same time. High-intensity aerobic exercise may help both, but Parkinson's symptoms make it hard for many to reach that intensity. Researchers at National Cheng-Kung University Hospital are testing whether walking on a treadmill at a gentler pace while inflatable cuffs restrict blood flow in the legs can improve dual-task balance, reduce anxiety, and change brain activity. The study plans to enroll 54 adults with early-to-moderate Parkinson's and measure posture, skin conductance, and EEG before and after exercise.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
aerobic exercise on a treadmill with inflatable blood flow restriction cuffs on the legs
What this could lead to
If it works, this could give people with Parkinson's a gentler way to train balance and anxiety than high-intensity exercise, which many cannot tolerate.
What could go wrong
The study is small and early, and it mixes exercise with cuffs, so researchers may not be able to tell which part helps. Blood flow restriction can cause discomfort or bruising, and results in 54 people may not apply to everyone with Parkinson's.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 54 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jul 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with idiopathic Parkinson's disease by a board-certified neurologist specializing in movement disorders. * Early-to-moderate stage of Parkinson's disease, corresponding to Hoehn and Yahr Stages 1 to 3 in the on-medication state. * Absence of other neurological or orthopedic conditions affecting balance and gait (e.g., stroke, vestibular disorders). * Mini-Mental State Examination (MMSE) score ≥ 26, indicating intact cognitive function without significant cognitive impairment. Exclusion Criteria: * Contraindications to blood flow restriction (BFR), including a history of cardiopulmonary disease, pneumonia, varicose veins, diabetes mellitus, or intermittent claudication; uncontrolled/unstable hypertension; active smoking; or currently taking medications that increase the risk of blood clots. * Presence of depressive symptoms that could influence postural control or anxiety assessments, defined as currently taking antidepressant medications or scoring \> 1 on item 1.3 (Depressed mood) of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part I. * History of neurosurgical procedures, such as Deep Brain Stimulation (DBS). * Color vision deficiency or color blindness, which interferes with the visual color discrimination task.

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anxiety Parkinson's disease (PD) Postural balance

How to take part

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  1. The official record

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