New combo may cut opioid need after spine surgery

NCT ID NCT06062550

First seen Apr 16, 2026 · Last updated Jun 13, 2026 · Updated 9 times

Summary

This study tests whether combining two drugs, esketamine and dexmedetomidine, at different doses can improve pain control after scoliosis correction surgery. The goal is to reduce the need for strong opioids and their side effects. About 312 adults undergoing scoliosis surgery will receive one of several drug combinations, and researchers will measure pain levels and opioid use for 72 hours after surgery.

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Contacts and locations

Locations

  • Beijing University First Hospital

    Beijing, Beijing Municipality, 100034, China

Conditions

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Conditions inferred from the trial description

These were inferred from the trial's summary, not listed by the trial registrant.