New lupus drug shows promise in Mid-Stage trial

NCT ID NCT05966480

Ongoing Disease control Sponsor: Alumis Inc Source: ClinicalTrials.gov ↗

First seen Apr 10, 2026 · Last updated May 13, 2026 · Updated 6 times

Summary

This study tests an experimental drug called ESK-001 in about 408 adults with active lupus. Participants receive either the drug or a placebo to see if it safely reduces disease activity over 48 weeks. The goal is to find a better treatment option for managing lupus.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Investigator Site # 2517

Naucalpan, State of Mexico, 54769, Mexico
Investigator Site # 6015

New Delhi, National Capital Territory of Delhi, 110 029, India
Investigator Site #1044

Memphis, Tennessee, 38119, United States
Investigator Site #1045

Clearwater, Florida, 33765, United States
Investigator Site #1046

Anniston, Alabama, 36207, United States
Investigator Site #1048

Aventura, Florida, 33180, United States
Investigator Site #1049

Colleyville, Texas, 76034, United States
Investigator Site #1050

Los Alamitos, California, 90720, United States
Investigator Site #1051

DeBary, Florida, 32713, United States
Investigator Site #1052

College Park, Georgia, 30329, United States
Investigator Site #1055

Coral Gables, Florida, 33134, United States
Investigator Site #1056

Charlotte, North Carolina, 28210, United States
Investigator Site #1057

Miami, Florida, 33176, United States
Investigator Site #1058

Brooklyn, New York, 11201, United States
Investigator Site #1060

Miami, Florida, 33136, United States
Investigator Site #1061

Upland, California, 91786, United States
Investigator Site #1062

Pittsburgh, Pennsylvania, 15224, United States
Investigator Site #1063

Avon Park, Florida, 33825, United States
Investigator Site #1067

Miami Lakes, Florida, 33014, United States
Investigator Site #1071

Fort Worth, Texas, 76177, United States
Investigator Site #1087

Hollywood, Florida, 33020, United States
Investigator Site #1088

New York, New York, 10032, United States
Investigator Site #1089

Tampa, Florida, 33606, United States
Investigator Site #1090

Plantation, Florida, 33324, United States
Investigator Site #1091

Daytona Beach, Florida, 32117, United States
Investigator Site #1093

Miami, Florida, 33155, United States
Investigator Site #1094

Houston, Texas, 77054, United States
Investigator Site #1095

Charlotte, North Carolina, 28207, United States
Investigator Site #1097

Coral Springs, Florida, 33071, United States
Investigator Site #1101

Albuquerque, New Mexico, 87102, United States
Investigator Site #1104

La Jolla, California, 92037, United States
Investigator Site #1135

Kissimmee, Florida, 34741, United States
Investigator Site #1168

Mission Hills, California, 91345, United States
Investigator Site #1169

Houston, Texas, 77095, United States
Investigator Site #1170

Atlanta, Georgia, 30328, United States
Investigator Site #1171

Philadelphia, Pennsylvania, 19114, United States
Investigator Site #1172

Spring, Texas, 77388, United States
Investigator Site #1173

Charlotte, North Carolina, 28277, United States
Investigator Site #1174

Napa, California, 94558, United States
Investigator Site #1175

Queens, New York, 11001, United States
Investigator Site #1176

Bradenton, Florida, 34209, United States
Investigator Site #1186

San Antonio, Texas, 78229, United States
Investigator Site #1187

Red Oak, Texas, 75154, United States
Investigator Site #1189

Sparta, New Jersey, 07871, United States
Investigator Site #1194

Tomball, Texas, 77375, United States
Investigator Site #1195

Carrollton, Texas, 75006, United States
Investigator Site #1204

Chesterfield, Missouri, 63017, United States
Investigator Site #2501

Chihuahua City, 31000, Mexico
Investigator Site #2502

Guadalajara, 44160, Mexico
Investigator Site #2503

Mexico City, 3720, Mexico
Investigator Site #2504

Cuauhtémoc, 6720, Mexico
Investigator Site #2505

San Luis Potosí City, 78213, Mexico
Investigator Site #2506

Mexico City, 6700, Mexico
Investigator Site #2507

Guadalajara, 44650, Mexico
Investigator Site #2508

Madero, 7760, Mexico
Investigator Site #2509

Mexico City, 14080, Mexico
Investigator Site #2510

Oaxaca City, 68000, Mexico
Investigator Site #2511

Mérida, 97070, Mexico
Investigator Site #2512

Guadalajara, 44620, Mexico
Investigator Site #2513

Torreón, 27000, Mexico
Investigator Site #2514

Mexico City, 3100, Mexico
Investigator Site #2516

Mérida, 97070, Mexico
Investigator Site #3001

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1221ADC, Argentina
Investigator Site #3002

Santiago, 75500587, Chile
Investigator Site #3003

Chía, 250001, Colombia
Investigator Site #3004

Lima, 15801, Peru
Investigator Site #3005

Santiago de Surco, 15023, Peru
Investigator Site #3006

Providencia, 7510586, Chile
Investigator Site #3008

Mendoza, Mendoza Province, M5500CPH, Argentina
Investigator Site #3009

San Miguel de Tucumán, Tucman, T4000BRD, Argentina
Investigator Site #3010

San Miguel de Tucumán, Tucman, T4000BRD, Argentina
Investigator Site #3011

Barranquilla, 80020, Colombia
Investigator Site #3012

CABA, Buenos Aires, C1425, Argentina
Investigator Site #3013

Lima, 15047, Peru
Investigator Site #3014

Medellín, 50034, Colombia
Investigator Site #3015

San Miguel de Tucumán, Tucumán Province, T4000, Argentina
Investigator Site #3016

La Plata, Buenos Aires, B1900, Argentina
Investigator Site #3017

Trujillo, 13001, Peru
Investigator Site #3018

San Martín de Porres, 15102, Peru
Investigator Site #3019

Barranquilla, 11111, Colombia
Investigator Site #3020

Cali, 760035, Colombia
Investigator Site #3021

Bogotá, 110221, Colombia
Investigator Site #3022

Bogotá, 504, Colombia
Investigator Site #3023

Buenos Aires, Buenos Aires, C1114 AAH, Argentina
Investigator Site #4002

Seville, 41014, Spain
Investigator Site #4003

Leipzig, 4103, Germany
Investigator Site #4005

Mainz, 55131, Germany
Investigator Site #4006

Munich, 80336, Germany
Investigator Site #4007

Barcelona, 8035, Spain
Investigator Site #4008

Alicante, 3699, Spain
Investigator Site #4009

Valencia, 46010, Spain
Investigator Site #4011

Køge, 4600, Denmark
Investigator Site #4012

Aarhus, Denmark
Investigator Site #4013

A Coruña, 15006, Spain
Investigator Site #4014

Southampton, SO16 6YD, United Kingdom
Investigator Site #4015

London, NW1 2BU, United Kingdom
Investigator Site #4016

London, SE1 7RT, United Kingdom
Investigator Site #4017

Leeds, LS1 3EX, United Kingdom
Investigator Site #5516

Tbilisi, 0168, Georgia
Investigator Site #5517

Tbilisi, Georgia
Investigator Site #5518

Bialystok, 15-707, Poland
Investigator Site #5519

Bialystok, 15-077, Poland
Investigator Site #5520

Bytom, Bytom, 41-902, Poland
Investigator Site #5521

Plovdiv, Bulgaria
Investigator Site #5522

Sofia, 1407, Bulgaria
Investigator Site #5523

Tbilisi, 102, Georgia
Investigator Site #5525

Plovdiv, 4003, Bulgaria
Investigator Site #5526

Bucharest, 11172, Romania
Investigator Site #5527

Warsaw, 00-215, Poland
Investigator Site #5528

Wroclaw, 50-088, Poland
Investigator Site #5529

Rousse, 7002, Bulgaria
Investigator Site #5530

Bucharest, 11025, Romania
Investigator Site #5531

Bydgoszcz, 85-168, Poland
Investigator Site #5532

Szczecin, 71-252, Poland
Investigator Site #5533

Krakow, 30-363, Poland
Investigator Site #5534

Tbilisi, 180, Georgia
Investigator Site #5535

Sosnowiec, 41-200, Poland
Investigator Site #5536

Tbilisi, 114, Georgia
Investigator Site #5537

Nadarzyn, 05-830, Poland
Investigator Site #5538

Tbilisi, 112, Georgia
Investigator Site #5539

Częstochowa, 42-200, Poland
Investigator Site #5540

Warsaw, 02-637, Poland
Investigator Site #5542

Rijeka, 51000, Croatia
Investigator Site #5543

Split, 21000, Croatia
Investigator Site #5544

Gyula, Hungary
Investigator Site #5545

Poznan, 61-397, Poland
Investigator Site #5546

Bialystok, 15-297, Poland
Investigator Site #5547

Sofia, 1463, Bulgaria
Investigator Site #5548

Debrecen, 4032, Hungary
Investigator Site #5549

Bucharest, 11057, Romania
Investigator Site #5602

Pleven, 2873, Bulgaria
Investigator Site #5603

Haskovo, 6300, Bulgaria
Investigator Site #6001

Bangalore, 560034, India
Investigator Site #6002

Surat, 395001, India
Investigator Site #6003

Surat, 395002, India
Investigator Site #6004

Haryāna, 122001, India
Investigator Site #6005

Ahmedabad, 380005, India
Investigator Site #6006

Ahmedabad, 380015, India
Investigator Site #6007

Pune, 411057, India
Investigator Site #6008

Nagpur, 440012, India
Investigator Site #6009

Bengaluru, 560010, India
Investigator Site #6010

Ahmedabad, 380006, India
Investigator Site #6011

Lucknow, 226014, India
Investigator Site #6012

Chandigarh, 160012, India
Investigator Site #6013

Jaipur, 302004, India
Investigator Site #6014

Pune, 411007, India
Investigator Site #6016

Ahmedabad, 380013, India
Investigator Site #8001

Manila, Philippines
Investigator Site #8003

Angeles City, Philippines
Investigator Site #8004

Busan, 49241, South Korea
Investigator Site #8006

Quezon City, Philippines
Investigator Site #8007

Anyang-si, 14068, South Korea
Investigator Site #8008

Taichung, 40201, Taiwan
Investigator Site #8009

Iloilo City, Philippines
Investigator Site #8010

Manila, Philippines
Investigator Site #8011

Lipa City, Philippines
Investigator Site #8012

Seoul, 6273, South Korea
Investigator Site #8013

Chiayi City, 622, Taiwan
Investigator Site #8014

Kaohsiung City, 11490, Taiwan
Investigator Site #8015

Taichung, 40447, Taiwan
Investigator Site #8016

Seoul, 3080, South Korea
Investigator Site #8017

Taipei, 100, Taiwan
Investigator Site #8018

Manila, Philippines
Investigator Site #8019

Seoul, 5030, South Korea
Investigator site #1053

San Antonio, Texas, 78215, United States
Investigator site #1178

Houston, Texas, 77386, United States
Investigator site #1209

Las Vegas, Nevada, 89102, United States
Investigator site #3028

Caguas, 00725, Puerto Rico
Investigator site #3029

San Juan, 00909-1908, Puerto Rico

Conditions

Explore the condition pages connected to this study.

SLE