Can a different opioid reduce Post-C-Section itching?

NCT ID NCT02277678

Completed Symptom relief Sponsor: KK Women's and Children's Hospital Source: ClinicalTrials.gov ↗

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial compares two epidural opioids—oxycodone and morphine—for pain relief after an elective cesarean section. The main focus is on how well each controls pain and how often they cause itching, a common side effect. Secondary goals include checking for nausea, vomiting, sedation, and breathing problems. About 100 women aged 21–50 who are having a planned C-section under combined spinal-epidural anesthesia will participate.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Epidural oxycodone compared with epidural morphine
What this could lead to: If oxycodone works as well as morphine for post-cesarean pain with less itching, it could become a preferred option for new mothers.
What could go wrong: This is a single trial with 100 participants, so results may not apply broadly. Both drugs can cause side effects like nausea, vomiting, or drowsiness.

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Conditions

The condition(s) this trial relates to.

Pruritus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRURITUS

Contacts and locations

Locations

KK Women's and Children's Hospital

Singapore, 229899, Singapore

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