PRURITUS

This study tests if a medicine called difelikefalin is safe for teenagers aged 12 to 17 who have severe itching due to kidney disease and are on dialysis. All 18 participants will receive the medicine during their regular dialysis visits for up to 12 weeks. The goal is to see if …

This study tests whether a relaxation technique called progressive muscle relaxation (PMR) — done with or without virtual reality (VR) — can help adult burn survivors manage ongoing symptoms like pain, itch, anxiety, sleep problems, and fatigue. About 34 participants will try bot…

This pilot study tests whether gentle neck traction can help people with nerve-related itching on the scalp, arms, or upper back use less medication. Twelve adults on stable doses of gabapentin or pregabalin will try home neck traction for 12 weeks. The goal is to see if this sim…

This study tests a drug called dupilumab for adults with severe, long-term itching that has no known cause. About 284 people aged 18 to 90 will receive either dupilumab or a placebo for 24 weeks, along with standard itch treatments. The goal is to see if dupilumab can safely redu…

This study looks at how often and how long itching occurs in people with drug-induced liver injury (DILI). Researchers will follow 50 adults with DILI or other liver conditions, using questionnaires to track itching symptoms. The goal is to better understand the problem and prepa…